Tzu-Ching Chen1, Ming H Hsieh2, Yi-Ting Lin2, Pei-Ying S Chan3, Chia-Hsiung Cheng4. 1. Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan; Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan. 2. Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan. 3. Department of Occupational Therapy and Graduate Institute of Behavioral Sciences, Chang Gung University, Taoyuan, Taiwan; Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan; Department of Psychiatry, Chang Gung Memorial Hospital, Linkou, Taiwan. 4. Department of Occupational Therapy and Graduate Institute of Behavioral Sciences, Chang Gung University, Taoyuan, Taiwan; Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan; Department of Psychiatry, Chang Gung Memorial Hospital, Linkou, Taiwan; Laboratory of Brain Imaging and Neural Dynamics (BIND Lab), Chang Gung University, Taoyuan, Taiwan. Electronic address: ch.cheng@mail.cgu.edu.tw.
Abstract
OBJECTIVE: Mismatch negativity (MMN) has been continuously used to evaluate the functional integrity of central auditory processing. However, it still remains inconclusive whether patients with autism spectrum disorder (ASD) demonstrate reduced MMN responses in all deviant types. METHODS: To reconcile the previous controversial findings, we performed a meta-analysis of peer-reviewed MMN articles concerning ASD. The potential moderators regarding different deviant types, diagnosis, and age on the effect sizes (Hedges' g) were also assessed. RESULTS: Compared to the controls, ASD patients showed reduced MMN amplitudes (g = -0.37, p = 0.001) and prolonged latencies (g = -0.33, p = 0.041) in response to speech-sound deviants. Children/adolescents with ASD manifested reduced MMN amplitudes in response to tone-duration deviants (g = -0.46, p = 0.014). Furthermore, the results showed significantly shortened MMN latencies to tone-frequency deviants in patients with autism (g = 0.29, p = 0.038) and, in contrast, prolonged MMN latencies (g = -0.74, p = 0.001) in patients with Asperger syndrome. CONCLUSION: MMN deficits are robust in ASD patients, suggesting an altered central ability in auditory discrimination. SIGNIFICANCE: MMN alterations were displayed in different profiles with respect to frequency, duration and phoneme changes.
OBJECTIVE: Mismatch negativity (MMN) has been continuously used to evaluate the functional integrity of central auditory processing. However, it still remains inconclusive whether patients with autism spectrum disorder (ASD) demonstrate reduced MMN responses in all deviant types. METHODS: To reconcile the previous controversial findings, we performed a meta-analysis of peer-reviewed MMN articles concerning ASD. The potential moderators regarding different deviant types, diagnosis, and age on the effect sizes (Hedges' g) were also assessed. RESULTS: Compared to the controls, ASDpatients showed reduced MMN amplitudes (g = -0.37, p = 0.001) and prolonged latencies (g = -0.33, p = 0.041) in response to speech-sound deviants. Children/adolescents with ASD manifested reduced MMN amplitudes in response to tone-duration deviants (g = -0.46, p = 0.014). Furthermore, the results showed significantly shortened MMN latencies to tone-frequency deviants in patients with autism (g = 0.29, p = 0.038) and, in contrast, prolonged MMN latencies (g = -0.74, p = 0.001) in patients with Asperger syndrome. CONCLUSION:MMN deficits are robust in ASDpatients, suggesting an altered central ability in auditory discrimination. SIGNIFICANCE: MMN alterations were displayed in different profiles with respect to frequency, duration and phoneme changes.
Authors: Giorgio Di Lorenzo; Assia Riccioni; Michele Ribolsi; Martina Siracusano; Paolo Curatolo; Luigi Mazzone Journal: Front Psychiatry Date: 2020-11-24 Impact factor: 4.157
Authors: Zachary J Williams; Peter G Abdelmessih; Alexandra P Key; Tiffany G Woynaroski Journal: Biol Psychiatry Cogn Neurosci Neuroimaging Date: 2020-09-22