[Indices of lipid free-radical oxidation and of antiradical protection of the brain--the neurochemical correlates of the development of the general adaptation syndrome].

The stage of rat long-term adaptation to chronic emotional-pain stress is characterized by an increase of superoxide dismutase brain activity and superoxide-scavenging blood serum activity, accumulation of fluorescent products of free-radical oxidation, reduction of phospholipids and cholesterin contents in the brain lipid extracts. In the process of prolonged adaptation to the continuing chronic emotional-pain stress three periods are singled out, each of which with a definite correlation of characteristics of vegetative functions, behaviour, intensity of free-radical oxidation and antiradical defence.