Literature DB >> 31951824

Human Cytomegalovirus Latency and Myelosuppression: A microRNA-Dependent Yin and Yang Regulatory Loop.

Lauren Gay1, Rolf Renne2.   

Abstract

In this issue of Cell Host & Microbe, Hancock et al., 2020 show that latent HCMV infection, and specifically miR-US5-2, induces TGF-β secretion, which inhibits myelopoiesis in uninfected HPCs. They also show that HCMV-infected cells become resistant to TGF-β signaling through targeting of SMAD3 by miR-UL22-A-3p and -5p.
Copyright © 2019 Elsevier Inc. All rights reserved.

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Year:  2020        PMID： 31951824      PMCID： PMC9168951          DOI： 10.1016/j.chom.2019.12.008

Source DB:  PubMed          Journal:  Cell Host Microbe        ISSN： 1931-3128            Impact factor:   31.316


  9 in total

Review 1.  New advances in the management of cytomegalovirus in allogeneic haemopoietic stem cell transplantation.

Authors:  Michelle K Yong; David Gottlieb; Julian Lindsay; Jen Kok; William Rawlinson; Monica Slavin; David Ritchie; Ashish Bajel; Andrew Grigg
Journal:  Intern Med J       Date:  2020-03       Impact factor: 2.048

2.  Cytomegalovirus in hematopoietic stem cell transplant recipients.

Authors:  Per Ljungman; Morgan Hakki; Michael Boeckh
Journal:  Hematol Oncol Clin North Am       Date:  2011-02       Impact factor: 3.722

Review 3.  TGF-beta signaling in tumor suppression and cancer progression.

Authors:  R Derynck; R J Akhurst; A Balmain
Journal:  Nat Genet       Date:  2001-10       Impact factor: 38.330

4.  A Kaposi's sarcoma-associated herpesvirus microRNA and its variants target the transforming growth factor β pathway to promote cell survival.

Authors:  Xiufen Lei; Ying Zhu; Tiffany Jones; Zhiqiang Bai; Yufei Huang; Shou-Jiang Gao
Journal:  J Virol       Date:  2012-08-22       Impact factor: 5.103

5.  Human Cytomegalovirus miRNAs Regulate TGF-β to Mediate Myelosuppression while Maintaining Viral Latency in CD34+ Hematopoietic Progenitor Cells.

Authors:  Meaghan H Hancock; Lindsey B Crawford; Andrew H Pham; Jennifer Mitchell; Hillary M Struthers; Andrew D Yurochko; Patrizia Caposio; Jay A Nelson
Journal:  Cell Host Microbe       Date:  2019-12-19       Impact factor: 21.023

6.  Epstein-Barr virus BARF1-induced NFκB/miR-146a/SMAD4 alterations in stomach cancer cells.

Authors:  Dong Ha Kim; Mee Soo Chang; Chan Jin Yoon; Jaap M Middeldorp; Olivia M Martinez; Sun-Ju Byeon; Sun Young Rha; Sung Han Kim; Yang Soo Kim; Jun Hee Woo
Journal:  Oncotarget       Date:  2016-12-13

Review 7.  The Dynamic Roles of TGF-β Signalling in EBV-Associated Cancers.

Authors:  Sharmila Velapasamy; Christopher W Dawson; Lawrence S Young; Ian C Paterson; Lee Fah Yap
Journal:  Cancers (Basel)       Date:  2018-07-27       Impact factor: 6.639

8.  Identification of cellular genes targeted by KSHV-encoded microRNAs.

Authors:  Mark A Samols; Rebecca L Skalsky; Ann M Maldonado; Alberto Riva; M Cecilia Lopez; Henry V Baker; Rolf Renne
Journal:  PLoS Pathog       Date:  2007-05-11       Impact factor: 6.823

9.  Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Induces the Oncogenic miR-17-92 Cluster and Down-Regulates TGF-β Signaling.

Authors:  Hong Seok Choi; Vaibhav Jain; Brian Krueger; Vickie Marshall; Chang Hee Kim; Joanna L Shisler; Denise Whitby; Rolf Renne
Journal:  PLoS Pathog       Date:  2015-11-06       Impact factor: 6.823
  9 in total
  1 in total

1.  A BMPR2/YY1 Signaling Axis Is Required for Human Cytomegalovirus Latency in Undifferentiated Myeloid Cells.

Authors:  Emma Poole; Maria Cristina Carlan da Silva; Chris Huang; Marianne Perera; Sarah Jackson; Ian J Groves; Mark Wills; Amer Rana; John Sinclair
Journal:  mBio       Date:  2021-06-01       Impact factor: 7.867
  1 in total

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