| Literature DB >> 31951549 |
Xun Chi1, Steven J Bensinger2.
Abstract
Type I interferons (IFNs) can reprogram the cholesterol biosynthetic pathway to facilitate innate immune responses. In this issue of Immunity, Xiao et al. (2020) reveal that type I IFN signaling and 7-dehydrocholesterol (7-DHC) accumulation form a positive feedback loop to amplify innate immune responses to control viral infections by activating AKT3.Entities:
Year: 2020 PMID： 31951549 DOI： 10.1016/j.immuni.2019.12.017
Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745