Literature DB >> 31951547

That Wasn't a Complement-Too Much C3 in Demyelinating Disease.

Wendy Xin1, Jonah R Chan2.   

Abstract

Multiple sclerosis is a chronic inflammatory disease characterized by demyelination in the central nervous system. In this issue of Immunity, Werneberg et al. report a striking loss of synapses driven by excessive microglial pruning early in demyelinating disease, which can be rescued by inhibiting the complement component C3.
Copyright © 2019 Elsevier Inc. All rights reserved.

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Year:  2020        PMID： 31951547      PMCID： PMC8057118          DOI： 10.1016/j.immuni.2019.12.014

Source DB:  PubMed          Journal:  Immunity        ISSN： 1074-7613            Impact factor:   31.745


  9 in total

Review 1.  The regulation of the complement system: insights from genetically-engineered mice.

Authors:  Daniel Turnberg; Marina Botto
Journal:  Mol Immunol       Date:  2003-09       Impact factor: 4.407

2.  Reconstruction of single cortical projection neurons reveals primary spine loss in multiple sclerosis.

Authors:  Tanja Jürgens; Mehrnoosh Jafari; Mario Kreutzfeldt; Erik Bahn; Wolfgang Brück; Martin Kerschensteiner; Doron Merkler
Journal:  Brain       Date:  2015-12-14       Impact factor: 13.501

3.  Demyelination causes synaptic alterations in hippocampi from multiple sclerosis patients.

Authors:  Ranjan Dutta; Ansi Chang; Mary K Doud; Grahame J Kidd; Michael V Ribaudo; Elizabeth A Young; Robert J Fox; Susan M Staugaitis; Bruce D Trapp
Journal:  Ann Neurol       Date:  2011-03       Impact factor: 10.422

4.  Microglia ablation alleviates myelin-associated catatonic signs in mice.

Authors:  Hana Janova; Sahab Arinrad; Evan Balmuth; Marina Mitjans; Johannes Hertel; Mohamad Habes; Robert A Bittner; Hong Pan; Sandra Goebbels; Martin Begemann; Ulrike C Gerwig; Sönke Langner; Hauke B Werner; Sarah Kittel-Schneider; Georg Homuth; Christos Davatzikos; Henry Völzke; Brian L West; Andreas Reif; Hans Jörgen Grabe; Susann Boretius; Hannelore Ehrenreich; Klaus-Armin Nave
Journal:  J Clin Invest       Date:  2017-12-18       Impact factor: 14.808

Review 5.  Multiple Sclerosis.

Authors:  Daniel S Reich; Claudia F Lucchinetti; Peter A Calabresi
Journal:  N Engl J Med       Date:  2018-01-11       Impact factor: 91.245

6.  Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner.

Authors:  Dorothy P Schafer; Emily K Lehrman; Amanda G Kautzman; Ryuta Koyama; Alan R Mardinly; Ryo Yamasaki; Richard M Ransohoff; Michael E Greenberg; Ben A Barres; Beth Stevens
Journal:  Neuron       Date:  2012-05-24       Impact factor: 17.173

7.  Targeted Complement Inhibition at Synapses Prevents Microglial Synaptic Engulfment and Synapse Loss in Demyelinating Disease.

Authors:  Sebastian Werneburg; Jonathan Jung; Rejani B Kunjamma; Seung-Kwon Ha; Nicholas J Luciano; Cory M Willis; Guangping Gao; Natalia P Biscola; Leif A Havton; Stephen J Crocker; Brian Popko; Daniel S Reich; Dorothy P Schafer
Journal:  Immunity       Date:  2019-12-26       Impact factor: 31.745

8.  The classical complement cascade mediates CNS synapse elimination.

Authors:  Beth Stevens; Nicola J Allen; Luis E Vazquez; Gareth R Howell; Karen S Christopherson; Navid Nouri; Kristina D Micheva; Adrienne K Mehalow; Andrew D Huberman; Benjamin Stafford; Alexander Sher; Alan M Litke; John D Lambris; Stephen J Smith; Simon W M John; Ben A Barres
Journal:  Cell       Date:  2007-12-14       Impact factor: 41.582

9.  Mouse complement regulatory protein Crry/p65 uses the specific mechanisms of both human decay-accelerating factor and membrane cofactor protein.

Authors:  Y U Kim; T Kinoshita; H Molina; D Hourcade; T Seya; L M Wagner; V M Holers
Journal:  J Exp Med       Date:  1995-01-01       Impact factor: 14.307
  9 in total
  1 in total

Review 1.  Microglial Pruning: Relevance for Synaptic Dysfunction in Multiple Sclerosis and Related Experimental Models.

Authors:  Maria Concetta Geloso; Nadia D'Ambrosi
Journal:  Cells       Date:  2021-03-20       Impact factor: 6.600
  1 in total

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