| Literature DB >> 31951535 |
Brianne Dentel1, Christine Ochoa Escamilla1, Peter T Tsai2.
Abstract
Dysregulated mTOR contributes to neurodevelopmental dysfunction. A new study (Chen et al., 2019) demonstrates that suppression of mTORC2, not mTORC1, ameliorates survival, seizures, and abnormal behaviors in a Pten mutant model, highlighting mTORC2 as a potential therapeutic target in mTORopathies.Entities:
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Year: 2019 PMID： 31951535 DOI： 10.1016/j.neuron.2019.11.026
Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173