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Literature DB >> 31951525

Antidepressant Effects and Mechanisms of Group II mGlu Receptor-Specific Negative Allosteric Modulators.

Liam E Potter¹, Panos Zanos², Todd D Gould³.

Abstract

In this issue of Neuron, Joffe et al. (2020) assess the antidepressant-relevant effects and underlying neural mechanisms of negative allosteric modulators selective for either metabotropic glutamate receptors 2 (mGlu2) or 3 (mGlu3). Negative modulation of both receptors enhanced excitatory glutamatergic input to mouse prefrontal cortex pyramidal cells, leading to antidepressant-relevant actions. Published by Elsevier Inc.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Antidepressive Agents

Year: 2020 PMID： 31951525 PMCID： PMC8011990 DOI： 10.1016/j.neuron.2019.12.011

Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173

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References

10 in total

1. The Antidepressant Effects of an mGlu2/3 Receptor Antagonist and Ketamine Require AMPA Receptor Stimulation in the mPFC and Subsequent Activation of the 5-HT Neurons in the DRN.

Authors: Kenichi Fukumoto; Michihiko Iijima; Shigeyuki Chaki
Journal: Neuropsychopharmacology Date: 2015-08-06 Impact factor: 7.853

2. Reciprocal Circuits Linking the Prefrontal Cortex with Dorsal and Ventral Thalamic Nuclei.

Authors: David P Collins; Paul G Anastasiades; Joseph J Marlin; Adam G Carter
Journal: Neuron Date: 2018-04-05 Impact factor: 17.173

Review 3. mGlu2/3 Receptor Antagonists as Novel Antidepressants.

Authors: Shigeyuki Chaki
Journal: Trends Pharmacol Sci Date: 2017-04-13 Impact factor: 14.819

Review 4. Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments.

Authors: Ronald S Duman; Gerard Sanacora; John H Krystal
Journal: Neuron Date: 2019-04-03 Impact factor: 17.173

5. mGlu₂ and mGlu₃ Negative Allosteric Modulators Divergently Enhance Thalamocortical Transmission and Exert Rapid Antidepressant-like Effects.

Authors: Max E Joffe; Chiaki I Santiago; Kendra H Oliver; James Maksymetz; Nicholas A Harris; Julie L Engers; Craig W Lindsley; Danny G Winder; P Jeffrey Conn
Journal: Neuron Date: 2019-11-14 Impact factor: 17.173

6. (2R,6R)-hydroxynorketamine exerts mGlu₂ receptor-dependent antidepressant actions.

Authors: Panos Zanos; Jaclyn N Highland; Brent W Stewart; Polymnia Georgiou; Carleigh E Jenne; Jacqueline Lovett; Patrick J Morris; Craig J Thomas; Ruin Moaddel; Carlos A Zarate; Todd D Gould
Journal: Proc Natl Acad Sci U S A Date: 2019-03-13 Impact factor: 11.205

Antidepressant Effects and Mechanisms of Group II mGlu Receptor-Specific Negative Allosteric Modulators.

1. The Antidepressant Effects of an mGlu2/3 Receptor Antagonist and Ketamine Require AMPA Receptor Stimulation in the mPFC and Subsequent Activation of the 5-HT Neurons in the DRN.

2. Reciprocal Circuits Linking the Prefrontal Cortex with Dorsal and Ventral Thalamic Nuclei.

Review 3. mGlu2/3 Receptor Antagonists as Novel Antidepressants.

Review 4. Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments.

5. mGlu₂ and mGlu₃ Negative Allosteric Modulators Divergently Enhance Thalamocortical Transmission and Exert Rapid Antidepressant-like Effects.

6. (2R,6R)-hydroxynorketamine exerts mGlu₂ receptor-dependent antidepressant actions.

Review 7. Molecular Pharmacology and Neurobiology of Rapid-Acting Antidepressants.

8. Synaptic Regulation of a Thalamocortical Circuit Controls Depression-Related Behavior.

Review 9. Experimental medication treatment approaches for depression.

10. Cell-Type Specificity of Callosally Evoked Excitation and Feedforward Inhibition in the Prefrontal Cortex.

Antidepressant Effects and Mechanisms of Group II mGlu Receptor-Specific Negative Allosteric Modulators.

1. The Antidepressant Effects of an mGlu2/3 Receptor Antagonist and Ketamine Require AMPA Receptor Stimulation in the mPFC and Subsequent Activation of the 5-HT Neurons in the DRN.

2. Reciprocal Circuits Linking the Prefrontal Cortex with Dorsal and Ventral Thalamic Nuclei.

Review 3. mGlu2/3 Receptor Antagonists as Novel Antidepressants.

Review 4. Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments.

5. mGlu2 and mGlu3 Negative Allosteric Modulators Divergently Enhance Thalamocortical Transmission and Exert Rapid Antidepressant-like Effects.

6. (2R,6R)-hydroxynorketamine exerts mGlu2 receptor-dependent antidepressant actions.

Review 7. Molecular Pharmacology and Neurobiology of Rapid-Acting Antidepressants.

8. Synaptic Regulation of a Thalamocortical Circuit Controls Depression-Related Behavior.

Review 9. Experimental medication treatment approaches for depression.

10. Cell-Type Specificity of Callosally Evoked Excitation and Feedforward Inhibition in the Prefrontal Cortex.

5. mGlu₂ and mGlu₃ Negative Allosteric Modulators Divergently Enhance Thalamocortical Transmission and Exert Rapid Antidepressant-like Effects.

6. (2R,6R)-hydroxynorketamine exerts mGlu₂ receptor-dependent antidepressant actions.