Literature DB >> 31951520

Stabilizing HIF to Ameliorate Anemia.

Richard A Voit1, Vijay G Sankaran2.   

Abstract

Erythropoietin (EPO) production in the kidney is regulated by the oxygen-sensing transcription factor HIF-1α, which is degraded under normoxic conditions by HIF-prolyl hydroxylase (HIF-PHD). Inhibition of HIF-PHD by roxadustat leads to increased EPO production, better iron absorption, and amelioration of anemia in chronic kidney disease (CKD).
Copyright © 2020. Published by Elsevier Inc.

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Year:  2020        PMID： 31951520     DOI： 10.1016/j.cell.2019.12.010

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  13 in total

Review 1.  Therapeutic angiogenesis-based strategy for peripheral artery disease.

Authors:  Jingxuan Han; Lailiu Luo; Olivia Marcelina; Vivi Kasim; Shourong Wu
Journal:  Theranostics       Date:  2022-06-27       Impact factor: 11.600

Review 2.  HIF-1α in Osteoarthritis: From Pathogenesis to Therapeutic Implications.

Authors:  Chu-Yang Zeng; Xi-Feng Wang; Fu-Zhou Hua
Journal:  Front Pharmacol       Date:  2022-07-05       Impact factor: 5.988

3.  Dysregulation of iron homeostasis and methamphetamine reward behaviors in Clk1-deficient mice.

Authors:  Peng-Ju Yan; Zhao-Xiang Ren; Zhi-Feng Shi; Chun-Lei Wan; Chao-Jun Han; Liu-Shuai Zhu; Ning-Ning Li; John L Waddington; Xue-Chu Zhen
Journal:  Acta Pharmacol Sin       Date:  2021-11-22       Impact factor: 7.169

4.  Erythrocyte transglutaminase-2 combats hypoxia and chronic kidney disease by promoting oxygen delivery and carnitine homeostasis.

Authors:  Ping Xu; Changhan Chen; Yujin Zhang; Monika Dzieciatkowska; Benjamin C Brown; Weiru Zhang; Tingting Xie; Osheiza Abdulmalik; Anren Song; Chao Tong; Hongbo Qi; Robert Roach; Rodney E Kellems; Angelo D'Alessandro; Yang Xia
Journal:  Cell Metab       Date:  2022-02-01       Impact factor: 31.373

5.  Loss of miR-145-5p Causes Ceruloplasmin Interference with PHD-Iron Axis and HIF-2α Stabilization in Lung Adenocarcinoma-Mediated Angiogenesis.

Authors:  Ying-Ming Tsai; Kuan-Li Wu; Yung-Yun Chang; Wei-An Chang; Yung-Chi Huang; Shu-Fang Jian; Pei-Hsun Tsai; Yi-Shiuan Lin; Inn-Wen Chong; Jen-Yu Hung; Ya-Ling Hsu
Journal:  Int J Mol Sci       Date:  2020-07-18       Impact factor: 5.923

Review 6.  The Interplay of Hypoxia Signaling on Mitochondrial Dysfunction and Inflammation in Cardiovascular Diseases and Cancer: From Molecular Mechanisms to Therapeutic Approaches.

Authors:  Esmaa Bouhamida; Giampaolo Morciano; Mariasole Perrone; Asrat E Kahsay; Mario Della Sala; Mariusz R Wieckowski; Francesco Fiorica; Paolo Pinton; Carlotta Giorgi; Simone Patergnani
Journal:  Biology (Basel)       Date:  2022-02-12

7.  The Application of Functional Magnetic Resonance Imaging in Type 2 Diabetes Rats With Contrast-Induced Acute Kidney Injury and the Associated Innate Immune Response.

Authors:  Yanfei Li; Dafa Shi; Haoran Zhang; Xiang Yao; Siyuan Wang; Rui Wang; Ke Ren
Journal:  Front Physiol       Date:  2021-06-29       Impact factor: 4.566

8.  Transcription-Based Multidimensional Regulation of Fatty Acid Metabolism by HIF1α in Renal Tubules.

Authors:  Wenju Li; Aiping Duan; Yuexian Xing; Li Xu; Jingping Yang
Journal:  Front Cell Dev Biol       Date:  2021-07-02

9.  Jian-Pi-Yi-Shen Regulates EPO and Iron Recycling Protein Expressions in Anemic Rats with Chronic Kidney Disease: Accumulation of Hypoxia Inducible Factor-2α via ERK Signaling.

Authors:  Fochang Wang; Huimin Yu; Shiying Huang; Lin Zheng; Ping Zheng; Shangbin Zhang; Shunmin Li; Jianping Chen
Journal:  Evid Based Complement Alternat Med       Date:  2020-10-30       Impact factor: 2.629

Review 10.  Time to Classify Tumours of the Stomach and the Kidneys According to Cell of Origin.

Authors:  Helge Waldum; Patricia Mjønes
Journal:  Int J Mol Sci       Date:  2021-12-13       Impact factor: 5.923
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