Literature DB >> 31951519

SnapShot: Splicing Alterations in Cancer.

Mohammad Alinoor Rahman1, Adrian R Krainer1, Omar Abdel-Wahab2.   

Abstract

RNA splicing, the spliceosome-catalyzed process by which pre-messenger RNA (pre-mRNA) is processed to mature mRNA, is altered in a number of ways in cancer. Tumor-specific splicing alterations are created by mutations that disrupt splicing-regulatory elements within genes and impair splicing recognition or by altering the RNA-binding preferences of individual splicing factors. This SnapShot summarizes our current understanding of splicing-factor alterations in cancers. To view this SnapShot, open or download the PDF.
Copyright © 2019 Elsevier Inc. All rights reserved.

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Year:  2020        PMID： 31951519      PMCID： PMC7291876          DOI： 10.1016/j.cell.2019.12.011

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  10 in total

Review 1.  The spliceosome: design principles of a dynamic RNP machine.

Authors:  Markus C Wahl; Cindy L Will; Reinhard Lührmann
Journal:  Cell       Date:  2009-02-20       Impact factor: 41.582

2.  SF3B1 and other novel cancer genes in chronic lymphocytic leukemia.

Authors:  Lili Wang; Michael S Lawrence; Youzhong Wan; Petar Stojanov; Carrie Sougnez; Kristen Stevenson; Lillian Werner; Andrey Sivachenko; David S DeLuca; Li Zhang; Wandi Zhang; Alexander R Vartanov; Stacey M Fernandes; Natalie R Goldstein; Eric G Folco; Kristian Cibulskis; Bethany Tesar; Quinlan L Sievers; Erica Shefler; Stacey Gabriel; Nir Hacohen; Robin Reed; Matthew Meyerson; Todd R Golub; Eric S Lander; Donna Neuberg; Jennifer R Brown; Gad Getz; Catherine J Wu
Journal:  N Engl J Med       Date:  2011-12-12       Impact factor: 91.245

3.  Frequent pathway mutations of splicing machinery in myelodysplasia.

Authors:  Kenichi Yoshida; Masashi Sanada; Yuichi Shiraishi; Daniel Nowak; Yasunobu Nagata; Ryo Yamamoto; Yusuke Sato; Aiko Sato-Otsubo; Ayana Kon; Masao Nagasaki; George Chalkidis; Yutaka Suzuki; Masashi Shiosaka; Ryoichiro Kawahata; Tomoyuki Yamaguchi; Makoto Otsu; Naoshi Obara; Mamiko Sakata-Yanagimoto; Ken Ishiyama; Hiraku Mori; Florian Nolte; Wolf-Karsten Hofmann; Shuichi Miyawaki; Sumio Sugano; Claudia Haferlach; H Phillip Koeffler; Lee-Yung Shih; Torsten Haferlach; Shigeru Chiba; Hiromitsu Nakauchi; Satoru Miyano; Seishi Ogawa
Journal:  Nature       Date:  2011-09-11       Impact factor: 49.962

4.  Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3' Splice Site Selection through Use of a Different Branch Point.

Authors:  Rachel B Darman; Michael Seiler; Anant A Agrawal; Kian H Lim; Shouyong Peng; Daniel Aird; Suzanna L Bailey; Erica B Bhavsar; Betty Chan; Simona Colla; Laura Corson; Jacob Feala; Peter Fekkes; Kana Ichikawa; Gregg F Keaney; Linda Lee; Pavan Kumar; Kaiko Kunii; Crystal MacKenzie; Mark Matijevic; Yoshiharu Mizui; Khin Myint; Eun Sun Park; Xiaoling Puyang; Anand Selvaraj; Michael P Thomas; Jennifer Tsai; John Y Wang; Markus Warmuth; Hui Yang; Ping Zhu; Guillermo Garcia-Manero; Richard R Furman; Lihua Yu; Peter G Smith; Silvia Buonamici
Journal:  Cell Rep       Date:  2015-10-22       Impact factor: 9.423

Review 5.  Misregulation of pre-mRNA alternative splicing in cancer.

Authors:  Jian Zhang; James L Manley
Journal:  Cancer Discov       Date:  2013-10-21       Impact factor: 39.397

6.  SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition.

Authors:  Eunhee Kim; Janine O Ilagan; Yang Liang; Gerrit M Daubner; Stanley C-W Lee; Aravind Ramakrishnan; Yue Li; Young Rock Chung; Jean-Baptiste Micol; Michele E Murphy; Hana Cho; Min-Kyung Kim; Ahmad S Zebari; Shlomzion Aumann; Christopher Y Park; Silvia Buonamici; Peter G Smith; H Joachim Deeg; Camille Lobry; Iannis Aifantis; Yorgo Modis; Frederic H-T Allain; Stephanie Halene; Robert K Bradley; Omar Abdel-Wahab
Journal:  Cancer Cell       Date:  2015-05-11       Impact factor: 31.743

7.  U2AF1 mutations alter splice site recognition in hematological malignancies.

Authors:  Janine O Ilagan; Aravind Ramakrishnan; Brian Hayes; Michele E Murphy; Ahmad S Zebari; Philip Bradley; Robert K Bradley
Journal:  Genome Res       Date:  2014-09-29       Impact factor: 9.043

Review 8.  Splicing-factor alterations in cancers.

Authors:  Olga Anczuków; Adrian R Krainer
Journal:  RNA       Date:  2016-09       Impact factor: 4.942

Review 9.  RNA splicing factors as oncoproteins and tumour suppressors.

Authors:  Heidi Dvinge; Eunhee Kim; Omar Abdel-Wahab; Robert K Bradley
Journal:  Nat Rev Cancer       Date:  2016-06-10       Impact factor: 60.716

10.  Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma.

Authors:  Hiromichi Suzuki; Sachin A Kumar; Shimin Shuai; Ander Diaz-Navarro; Ana Gutierrez-Fernandez; Pasqualino De Antonellis; Florence M G Cavalli; Kyle Juraschka; Hamza Farooq; Ichiyo Shibahara; Maria C Vladoiu; Jiao Zhang; Namal Abeysundara; David Przelicki; Patryk Skowron; Nicole Gauer; Betty Luu; Craig Daniels; Xiaochong Wu; Antoine Forget; Ali Momin; Jun Wang; Weifan Dong; Seung-Ki Kim; Wieslawa A Grajkowska; Anne Jouvet; Michelle Fèvre-Montange; Maria Luisa Garrè; Amulya A Nageswara Rao; Caterina Giannini; Johan M Kros; Pim J French; Nada Jabado; Ho-Keung Ng; Wai Sang Poon; Charles G Eberhart; Ian F Pollack; James M Olson; William A Weiss; Toshihiro Kumabe; Enrique López-Aguilar; Boleslaw Lach; Maura Massimino; Erwin G Van Meir; Joshua B Rubin; Rajeev Vibhakar; Lola B Chambless; Noriyuki Kijima; Almos Klekner; László Bognár; Jennifer A Chan; Claudia C Faria; Jiannis Ragoussis; Stefan M Pfister; Anna Goldenberg; Robert J Wechsler-Reya; Swneke D Bailey; Livia Garzia; A Sorana Morrissy; Marco A Marra; Xi Huang; David Malkin; Olivier Ayrault; Vijay Ramaswamy; Xose S Puente; John A Calarco; Lincoln Stein; Michael D Taylor
Journal:  Nature       Date:  2019-10-09       Impact factor: 49.962
  10 in total
  24 in total

1.  Alterations of RNA splicing patterns in esophagus squamous cell carcinoma.

Authors:  Jiyu Ding; Chunquan Li; Yinwei Cheng; Zepeng Du; Qiuyu Wang; Zhidong Tang; Chao Song; Qiaoxi Xia; Wenjing Bai; Ling Lin; Wei Liu; Liyan Xu; Enmin Li; Bingli Wu
Journal:  Cell Biosci       Date:  2021-02-09       Impact factor: 7.133

Review 2.  RNA-binding proteins in human genetic disease.

Authors:  Fátima Gebauer; Thomas Schwarzl; Juan Valcárcel; Matthias W Hentze
Journal:  Nat Rev Genet       Date:  2020-11-24       Impact factor: 53.242

Review 3.  Intronic Polyadenylation in Acquired Cancer Drug Resistance Circumvented by Utilizing CRISPR/Cas9 with Homology-Directed Repair: The Tale of Human DNA Topoisomerase IIα.

Authors:  Terry S Elton; Victor A Hernandez; Jessika Carvajal-Moreno; Xinyi Wang; Deborah Ipinmoroti; Jack C Yalowich
Journal:  Cancers (Basel)       Date:  2022-06-27       Impact factor: 6.575

Review 4.  Roles and mechanisms of alternative splicing in cancer - implications for care.

Authors:  Sophie C Bonnal; Irene López-Oreja; Juan Valcárcel
Journal:  Nat Rev Clin Oncol       Date:  2020-04-17       Impact factor: 66.675

Review 5.  Splicing regulation in hematopoiesis.

Authors:  Sisi Chen; Omar Abdel-Wahab
Journal:  Curr Opin Hematol       Date:  2021-07-01       Impact factor: 3.218

Review 6.  Therapeutic Modulation of RNA Splicing in Malignant and Non-Malignant Disease.

Authors:  Ettaib El Marabti; Omar Abdel-Wahab
Journal:  Trends Mol Med       Date:  2021-05-13       Impact factor: 15.272

7.  Splicing Factor Mutations and Disease Phenotype: Searching for a Needle in a Haystack.

Authors:  Kevin Rouault-Pierre
Journal:  Hemasphere       Date:  2021-06-01

8.  KRT18 Modulates Alternative Splicing of Genes Involved in Proliferation and Apoptosis Processes in Both Gastric Cancer Cells and Clinical Samples.

Authors:  Biao Chen; Ximing Xu; Dan-Dan Lin; Xin Chen; Yang-Tao Xu; Xin Liu; Wei-Guo Dong
Journal:  Front Genet       Date:  2021-07-05       Impact factor: 4.599

Review 9.  Emerging roles of spliceosome in cancer and immunity.

Authors:  Hui Yang; Bruce Beutler; Duanwu Zhang
Journal:  Protein Cell       Date:  2021-07-01       Impact factor: 15.328

10.  RNA binding motif protein 10 suppresses lung cancer progression by controlling alternative splicing of eukaryotic translation initiation factor 4H.

Authors:  Sirui Zhang; Yufang Bao; Xianfeng Shen; Yunjian Pan; Yue Sun; Man Xiao; Kexuan Chen; Huanhuan Wei; Ji Zuo; David Saffen; Wei-Xing Zong; Yihua Sun; Zefeng Wang; Yongbo Wang
Journal:  EBioMedicine       Date:  2020-10-23       Impact factor: 11.205
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