| Literature DB >> 31951057 |
Selvadasan Vinayagamani1, R Sheelakumari1, Sekar Sabarish1, Santhakumar Senthilvelan1, Roopa Ros2, Bejoy Thomas1, Chandrasekharan Kesavadas1.
Abstract
Quantitative susceptibility mapping (QSM) is a novel magnetic resonance imaging (MRI) technique for quantifying the spatial distribution of magnetic susceptibility within an object or tissue. Recently, QSM has been widely used to study various dominant magnetic susceptibility sources in the brain, including iron and calcium. In addition, the method enables mapping of the cerebral metabolic rate of oxygen, which could act as a new metabolic biomarker for diseases that involve disruption of the brain's oxygen supply. Thus, the clinical applications of QSM are wide-reaching and hold great promise as imaging biomarkers for studying several neurological diseases. This review aims to summarize the physical concepts and potential clinical applications of QSM in neuroimaging. EVIDENCE LEVEL: 5 TECHNICAL EFFICACY: Stage 2.Entities:
Keywords: clinical applications; iron quantification; quantitative susceptibility mapping; venous oxygen saturation
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Year: 2020 PMID: 31951057 DOI: 10.1002/jmri.27058
Source DB: PubMed Journal: J Magn Reson Imaging ISSN: 1053-1807 Impact factor: 4.813