Literature DB >> 31950936

A novel near-infrared fluorescent probe for detection of early-stage Aβ protofibrils in Alzheimer's disease.

Guanglei Lv1, Anyang Sun, Minqi Wang, Peng Wei, Ruohan Li, Tao Yi.   

Abstract

Detection of Aβ protofibrils at the early stage of Alzheimer's disease was realized by a novel near-infrared probe (DCM-AN) based on dicyanomethylene-4H-pyran. This probe exhibits high affinity towards Aβ protofibrils in vitro and in brain sections of transgenic mouse models for Alzheimer's disease.

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Year:  2020        PMID： 31950936     DOI： 10.1039/c9cc09233a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  3 in total

1.  Seeding and Growth of β-Amyloid Aggregates upon Interaction with Neuronal Cell Membranes.

Authors:  Álvaro Ruiz-Arias; Jose M Paredes; Chiara Di Biase; Juan M Cuerva; María D Giron; Rafael Salto; Juan A González-Vera; Angel Orte
Journal:  Int J Mol Sci       Date:  2020-07-16       Impact factor: 5.923

2.  Versatile Dicyanomethylene-Based Fluorescent Probes for the Detection of β-Amyloid in Alzheimer's Disease: A Theoretical Perspective.

Authors:  Mengna Zhang; Haoqing Fu; Wei Hu; Jiancai Leng; Yujin Zhang
Journal:  Int J Mol Sci       Date:  2022-08-03       Impact factor: 6.208

3.  Amphiphilic Distyrylbenzene Derivatives as Potential Therapeutic and Imaging Agents for Soluble and Insoluble Amyloid β Aggregates in Alzheimer's Disease.

Authors:  Liang Sun; Hong-Jun Cho; Soumyo Sen; Andres S Arango; Truc T Huynh; Yiran Huang; Nilantha Bandara; Buck E Rogers; Emad Tajkhorshid; Liviu M Mirica
Journal:  J Am Chem Soc       Date:  2021-07-02       Impact factor: 15.419
  3 in total

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