Bangxu Yu1, Aiqin Li2, Mao Zhang3, Haoran Li3, Cheng Tao4, Bing Han3. 1. Department of Surgical Intensive Care Unit, The Affiliated Hospital of Qingdao University Qingdao, Shandong, P. R. China. 2. Department of Out-patient and Emergency, The Affiliated Hospital of Qingdao University Qingdao, Shandong, P. R. China. 3. Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Qingdao University Qingdao, Shandong, P. R. China. 4. Department of Scientific Research Management, The Affiliated Hospital of Qingdao University Qingdao, Shandong, P. R. China.
Abstract
OBJECTIVE: To study the relationship between interleukin (IL)-1β and nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) expressions in tumor tissue and the recurrence of hepatocellular carcinoma (HCC) after hepatectomy. METHODS: The expressions of IL-1β and NFκB in tumor tissues of 92 patients with HCC were measured using immunohistochemical staining. The correlations between IL-1β and NFκB expressions with clinical factors and postoperative recurrence were analyzed. RESULTS: Compared with the low expression group, the disease-free survival (DFS) of HCC with high expression of IL-1β and NFκB was more significantly prolonged (P < 0.05). NFκB is a key molecule in the downstream signaling pathway of IL-1β, and the expression of IL-1β and NFκB is positively associated with serum total bilirubin (TBIL). IL-1β and NFκB levels and platelet (PLT) levels were independent risk factors for postoperative recurrence of HCC (P < 0.05). CONCLUSIONS: The low expressions of IL-1β and NFκB in HCC tissues are an independent risk factor for the recurrence of HCC after hepatectomy, but a high expression can significantly prolong DFS. IJCEP
OBJECTIVE: To study the relationship between interleukin (IL)-1β and nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) expressions in tumor tissue and the recurrence of hepatocellular carcinoma (HCC) after hepatectomy. METHODS: The expressions of IL-1β and NFκB in tumor tissues of 92 patients with HCC were measured using immunohistochemical staining. The correlations between IL-1β and NFκB expressions with clinical factors and postoperative recurrence were analyzed. RESULTS: Compared with the low expression group, the disease-free survival (DFS) of HCC with high expression of IL-1β and NFκB was more significantly prolonged (P < 0.05). NFκB is a key molecule in the downstream signaling pathway of IL-1β, and the expression of IL-1β and NFκB is positively associated with serum total bilirubin (TBIL). IL-1β and NFκB levels and platelet (PLT) levels were independent risk factors for postoperative recurrence of HCC (P < 0.05). CONCLUSIONS: The low expressions of IL-1β and NFκB in HCC tissues are an independent risk factor for the recurrence of HCC after hepatectomy, but a high expression can significantly prolong DFS. IJCEP
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