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Literature DB >> 31948752

Topologies of G-quadruplex: Biological functions and regulation by ligands.

Yue Ma¹, Keisuke Iida², Kazuo Nagasawa³.

Abstract

G-Quadruplex (G4) is one of the higher-order structures occurring in guanine-rich sequences of nucleic acids, and plays critical roles in biological processes. The G4-forming sequences can generate three kinds of topologies, i.e., parallel, anti-parallel, and hybrid, and these polymorphic structures have an important influence on G4-related biological functions. In this review, we highlight variety of structures generated by G4s containing various sequences and under diverse conditions. We also discuss the G4 ligands which induce specific topologies and/or conversion between different topologies.

Entities: Chemical

Keywords: G-quadruplex; G4 ligand; G4 topology

Mesh：

Substances：

Year: 2020 PMID： 31948752 DOI： 10.1016/j.bbrc.2019.12.103

Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575

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Cited

9 in total

Review 1. Discriminating between Parallel, Anti-Parallel and Hybrid G-Quadruplexes: Mechanistic Details on Their Binding to Small Molecules.

Authors: Tarita Biver
Journal: Molecules Date: 2022-06-29 Impact factor: 4.927

2. Combining Electrospray Mass Spectrometry (ESI-MS) and Computational Techniques in the Assessment of G-Quadruplex Ligands: A Hybrid Approach to Optimize Hit Discovery.

Authors: Giovanni Ribaudo; Alberto Ongaro; Erika Oselladore; Maurizio Memo; Alessandra Gianoncelli
Journal: J Med Chem Date: 2021-09-12 Impact factor: 7.446

Review 3. The Interactions of H₂TMPyP, Analogues and Its Metal Complexes with DNA G-Quadruplexes-An Overview.

Authors: Catarina I V Ramos; Ana R Monteiro; Nuno M M Moura; Maria Amparo F Faustino; Tito Trindade; Maria Graça P M S Neves
Journal: Biomolecules Date: 2021-09-25

4. Linear consecutive hexaoxazoles as G4 ligands inducing chair-type anti-parallel topology of a telomeric G-quadruplex.

Authors: Shogo Sasaki; Yue Ma; Takumi Ishizuka; Hong-Liang Bao; Takatsugu Hirokawa; Yan Xu; Masayuki Tera; Kazuo Nagasawa
Journal: RSC Adv Date: 2020-12-07 Impact factor: 4.036

5. Development of a novel light-up probe for detection of G-quadruplexes in stress granules.

Authors: Keisuke Iida; Natsumi Suzuki; Ayano Sasaki; Shunsuke Ishida; Takayoshi Arai
Journal: Sci Rep Date: 2022-07-28 Impact factor: 4.996

6. Multiple G-quadruplex binding ligand induced transcriptomic map of cancer cell lines.

Authors: Amjesh Revikumar; Vivek Kashyap; Akhina Palollathil; Anjana Aravind; Rajeswari Raguraman; Kenkere Mallikarjunaiah Kiran Kumar; Manavalan Vijayakumar; Thottethodi Subrahmanya Keshava Prasad; Rajesh Raju
Journal: J Cell Commun Signal Date: 2021-07-26 Impact factor: 5.782

Topologies of G-quadruplex: Biological functions and regulation by ligands.

Review 1. Discriminating between Parallel, Anti-Parallel and Hybrid G-Quadruplexes: Mechanistic Details on Their Binding to Small Molecules.

2. Combining Electrospray Mass Spectrometry (ESI-MS) and Computational Techniques in the Assessment of G-Quadruplex Ligands: A Hybrid Approach to Optimize Hit Discovery.

Review 3. The Interactions of H₂TMPyP, Analogues and Its Metal Complexes with DNA G-Quadruplexes-An Overview.

4. Linear consecutive hexaoxazoles as G4 ligands inducing chair-type anti-parallel topology of a telomeric G-quadruplex.

5. Development of a novel light-up probe for detection of G-quadruplexes in stress granules.

6. Multiple G-quadruplex binding ligand induced transcriptomic map of cancer cell lines.

7. Towards Profiling of the G-Quadruplex Targeting Drugs in the Living Human Cells Using NMR Spectroscopy.

8. Constrained G4 structures unveil topology specificity of known and new G4 binding proteins.

Review 9. Major Achievements in the Design of Quadruplex-Interactive Small Molecules.

Topologies of G-quadruplex: Biological functions and regulation by ligands.

Review 1. Discriminating between Parallel, Anti-Parallel and Hybrid G-Quadruplexes: Mechanistic Details on Their Binding to Small Molecules.

2. Combining Electrospray Mass Spectrometry (ESI-MS) and Computational Techniques in the Assessment of G-Quadruplex Ligands: A Hybrid Approach to Optimize Hit Discovery.

Review 3. The Interactions of H2TMPyP, Analogues and Its Metal Complexes with DNA G-Quadruplexes-An Overview.

4. Linear consecutive hexaoxazoles as G4 ligands inducing chair-type anti-parallel topology of a telomeric G-quadruplex.

5. Development of a novel light-up probe for detection of G-quadruplexes in stress granules.

6. Multiple G-quadruplex binding ligand induced transcriptomic map of cancer cell lines.

7. Towards Profiling of the G-Quadruplex Targeting Drugs in the Living Human Cells Using NMR Spectroscopy.

8. Constrained G4 structures unveil topology specificity of known and new G4 binding proteins.

Review 9. Major Achievements in the Design of Quadruplex-Interactive Small Molecules.

Review 3. The Interactions of H₂TMPyP, Analogues and Its Metal Complexes with DNA G-Quadruplexes-An Overview.