Speckle Reduction in Optical Coherence Tomography via Super-Resolution Reconstruction.

Reducing speckle noise from the optical coherence tomograms (OCT) of human retina is a fundamental step to a better visualization and analysis in retinal imaging, as thus to support examination, diagnosis and treatment of many eye diseases. In this study, we propose a new method for speckle reduction in OCT images using the super-resolution technology. It merges multiple images for the same scene but with sub-pixel movements and restores the missing signals in one pixel, which significantly improves the image quality. The proposed method is evaluated on a dataset of 20 OCT volumes (5120 images), through the mean square error, peak signal to noise ratio and the mean structure similarity index using high quality line-scan images as reference. The experimental results show that the proposed method outperforms existing state-of-the-art approaches in applicability, effectiveness, and accuracy.