| Literature DB >> 31945671 |
Bana Shriky1, Adrian Kelly2, Mohammad Isreb3, Maksims Babenko4, Najet Mahmoudi5, Sarah Rogers6, Olga Shebanova7, Tim Snow8, Tim Gough9.
Abstract
Understanding structure-property relationships is critical for the development of new drug delivery systems. This study investigates the properties of Pluronic smart hydrogel formulations for future use as injectable controlled drug carriers. The smart hydrogels promise to enhance patient compliance, decrease side effects and reduce dose and frequency. Pharmaceutically, these systems are attractive due to their unique sol-gel phase transition in the body, biocompatibility, safety and injectability as solutions before transforming into gel matrices at body temperature. We quantify the structural changes of F127 systems under controlled temperature after flow, as experienced during real bodily injection. Empirical formulae combining the coupled thermal and shear dependency are produced to aid future application of these systems. Induced structural transitions measured in-situ by small angle x-ray and neutron scattering reveal mixed oriented structures that can be exploited to tailor the drug release profile.Entities:
Keywords: Colloidal crystals; Drug delivery systems; Drug release; Gel; Injectables; Pluronic; Rheological properties; SANS; SAXS; Thermal properties; Thermosensitive
Year: 2019 PMID： 31945671 DOI： 10.1016/j.jcis.2019.12.096
Source DB: PubMed Journal: J Colloid Interface Sci ISSN： 0021-9797 Impact factor: 8.128