Literature DB >> 31941705

The roles of TET family proteins in development and stem cells.

Jihong Yang1, Nazym Bashkenova1, Ruge Zang1,2, Xin Huang1, Jianlong Wang3.   

Abstract

Ten-eleven translocation (TET) methylcytosine dioxygenases are enzymes that catalyze the demethylation of 5-methylcytosine on DNA. Through global and site-specific demethylation, they regulate cell fate decisions during development and in embryonic stem cells by maintaining pluripotency or by regulating differentiation. In this Primer, we provide an updated overview of TET functions in development and stem cells. We discuss the catalytic and non-catalytic activities of TETs, and their roles as epigenetic regulators of both DNA and RNA hydroxymethylation, highlighting how TET proteins function in regulating gene expression at both the transcriptional and post-transcriptional levels.
© 2020. Published by The Company of Biologists Ltd.

Entities:  

Keywords:  DNA demethylation; Differentiation; Pluripotency; TET

Mesh：

Substances：

Year:  2020        PMID： 31941705      PMCID： PMC6983710          DOI： 10.1242/dev.183129

Source DB:  PubMed          Journal:  Development        ISSN： 0950-1991            Impact factor:   6.868


  112 in total

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Journal:  Trends Genet       Date:  2016-11-23       Impact factor: 11.639

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Journal:  Nature       Date:  2011-03-30       Impact factor: 49.962

4.  The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes.

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Journal:  Nature       Date:  2011-09-04       Impact factor: 49.962

5.  Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells.

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Journal:  Proc Natl Acad Sci U S A       Date:  2014-01-13       Impact factor: 11.205

6.  Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion.

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7.  Developmentally linked human DNA hypermethylation is associated with down-modulation, repression, and upregulation of transcription.

Authors:  Carl Baribault; Kenneth C Ehrlich; V K Chaithanya Ponnaluri; Sriharsa Pradhan; Michelle Lacey; Melanie Ehrlich
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  12 in total

1.  Small Molecule Inhibitors of TET Dioxygenases: Bobcat339 Activity Is Mediated by Contaminating Copper(II).

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Review 2.  The Methylation Game: Epigenetic and Epitranscriptomic Dynamics of 5-Methylcytosine.

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Review 5.  The Epigenetic Role of Vitamin C in Neurodevelopment.

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6.  TET1 regulates gene expression and repression of endogenous retroviruses independent of DNA demethylation.

Authors:  Paul Stolz; Angelo Salazar Mantero; Andrey Tvardovskiy; Enes Ugur; Lucas E Wange; Christopher B Mulholland; Yuying Cheng; Michael Wierer; Wolfgang Enard; Robert Schneider; Till Bartke; Heinrich Leonhardt; Simon J Elsässer; Sebastian Bultmann
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7.  Induced hepatic stem cells maintain self-renewal through the high expression of Myc coregulated by TET1 and CTCF.

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9.  Ascorbic Acid Promotes Functional Restoration after Spinal Cord Injury Partly by Epigenetic Modulation.

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Review 10.  Epigenetic regulation of retinal development.

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