Yongfeng Li1, Zhe Zhang2, Ying Yang3, Jun Ma4,5. 1. Department of Gastroenterology, Zhuji People's Hospital of Zhejiang Province, Zhuji, PR China. 2. Department of General Surgery, Tongde Hospital of Zhejiang Province, Hangzhou, PR China. 3. Department of Surgery, Hangzhou Hospital for the Prevention and Treatment of Occupational Disease, Hangzhou, PR China. 4. Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, PR China. 5. Key Laboratory of Gastroenterology of Zhejiang Province, Hangzhou, Zhejiang, PR China.
Abstract
Objective: To study the correlation between the long noncoding RNA HOX transcript antisense RNA (HOTAIR) gene rs17720428 single nucleotide polymorphism (SNP) and gastric cancer risk and prognosis. Methods: A case-control study was designed to assess the correlation between the HOTAIR rs17720428 SNP and gastric cancer risk in the Chinese Han population. The genotype of the HOTAIR rs17720428 locus was analyzed in 245 patients with gastric cancer and 245 healthy control subjects by Sanger sequencing. Results: The gastric cancer risk in patients with a G allele at the HOTAIR rs17720428 locus was 1.59 times higher than that in patients with a T allele (95% confidence interval [CI]: 1.16-2.17, p < 0.01). This SNP of HOTAIR rs17720428 locus was associated with an increased risk for developing gastric cancer in males (male: adjusted odds ratio = 1.60, 95% CI = 1.02-2.52, p = 0.04). Patients with the GG genotype at the HOTAIR rs17720428 locus had the lowest overall survival (OS) (16.4 months), followed by those with the TG (19.3 months) and TT (24.2 months) genotypes. The differences in OS were statistically significant among the different genotypes (p = 0.003). Conclusion: The HOTAIR rs17720428 SNP is correlated with the risk and prognosis of gastric cancer in the Chinese Han population. The presence of a G allele at this locus increases the risk of gastric cancer among males.
Objective: To study the correlation between the long noncoding RNA HOX transcript antisense RNA (HOTAIR) gene rs17720428 single nucleotide polymorphism (SNP) and gastric cancer risk and prognosis. Methods: A case-control study was designed to assess the correlation between the HOTAIRrs17720428 SNP and gastric cancer risk in the Chinese Han population. The genotype of the HOTAIRrs17720428 locus was analyzed in 245 patients with gastric cancer and 245 healthy control subjects by Sanger sequencing. Results: The gastric cancer risk in patients with a G allele at the HOTAIRrs17720428 locus was 1.59 times higher than that in patients with a T allele (95% confidence interval [CI]: 1.16-2.17, p < 0.01). This SNP of HOTAIRrs17720428 locus was associated with an increased risk for developing gastric cancer in males (male: adjusted odds ratio = 1.60, 95% CI = 1.02-2.52, p = 0.04). Patients with the GG genotype at the HOTAIRrs17720428 locus had the lowest overall survival (OS) (16.4 months), followed by those with the TG (19.3 months) and TT (24.2 months) genotypes. The differences in OS were statistically significant among the different genotypes (p = 0.003). Conclusion: The HOTAIRrs17720428 SNP is correlated with the risk and prognosis of gastric cancer in the Chinese Han population. The presence of a G allele at this locus increases the risk of gastric cancer among males.
Authors: Sara Kashani; Hosein Ali Sasan; Gholamreza Bahari; Behrouz Mollashahi; Seyed Mehdi Hashemi; Mohsen Taheri Journal: Asian Pac J Cancer Prev Date: 2021-09-01