Mutagenicity testing of vincristine sulfate in germ cells of male mice.

Vincristine sulfate (VCR) affects the fertilization ability of all germ-cell stages in male mice. The reduced fertilization ability leads to a pseudo-dominant-lethal effect and sterile matings. The frequency of these effects is dose-dependent. The frequency of specific-locus mutations was not increased by VCR in male mice following 2 mg/kg bw treatment.