José Luiz Pinto Pereira1,2,3, José Luiz Pedroso4, Orlando G P Barsottini4, Alex Tiburtino Meira5, Hélio A G Teive5. 1. Prefeitura Municipal de Curitiba, Serviço de Atendimento Móvel de Urgência (SAMU), Curitiba PR, Brasil. 2. Hospital John Hopkins, Investigações Genéticas (1999-2000), EUA. 3. Instituto Kennedy Krieger, Investigações Genéticas (1999-2000), EUA. 4. Universidade Federal de São Paulo, Departamento de Neurologia, São Paulo SP, Brasil. 5. Universidade Federal do Paraná, Departamento de Medicina Interna, Serviço de Neurologia, Curitiba PR, Brasil.
Abstract
OBJECTIVE: A brief history of the syndrome discovered by Andreas Rett is reported in this paper. METHODS: Although having been described in 1966, the syndrome was only recognized by the international community after a report by Hagberg et al. in 1983. Soon, its importance was evident as a relatively frequent cause of severe encephalopathy among girls. CONCLUSION: From the beginning it was difficult to explain the absence of male patients and the almost total predominance of sporadic cases (99%), with very few familial cases. For these reasons, it was particularly difficult to investigate this condition until 1997, when a particular Brazilian family greatly helped in the final discovery of the gene, and in the clarification of its genetic mechanism. RESULTS: Brief references are made to the importance of the MECP2 gene, 18 years later, as well as to its role in synaptogenesis and future prospects.
OBJECTIVE: A brief history of the syndrome discovered by Andreas Rett is reported in this paper. METHODS: Although having been described in 1966, the syndrome was only recognized by the international community after a report by Hagberg et al. in 1983. Soon, its importance was evident as a relatively frequent cause of severe encephalopathy among girls. CONCLUSION: From the beginning it was difficult to explain the absence of male patients and the almost total predominance of sporadic cases (99%), with very few familial cases. For these reasons, it was particularly difficult to investigate this condition until 1997, when a particular Brazilian family greatly helped in the final discovery of the gene, and in the clarification of its genetic mechanism. RESULTS: Brief references are made to the importance of the MECP2 gene, 18 years later, as well as to its role in synaptogenesis and future prospects.