| Literature DB >> 31939480 |
Edward O List1, Darlene E Berryman1,2, Elizabeth A Jensen1, Prateek Kulkarni1, Savannah McKenna1, John J Kopchick1,2.
Abstract
In order to provide new insights into the various activities of GH in specific tissues, recent advances have allowed for the generation of tissue-specific GHR knockout mice. To date, 21 distinct tissue-specific mouse lines have been created and reported in 28 publications. Targeted tissues include liver, muscle, fat, brain, bone, heart, intestine, macrophage, pancreatic beta cells, hematopoietic stem cells, and multi-tissue "global". In this review, we provide a brief history and description of the 21 tissue-specific GHR knockout mouse lines. Arch Endocrinol Metab. 2019;63(6):557-67.Entities:
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Year: 2019 PMID： 31939480 DOI： 10.20945/2359-3997000000185
Source DB: PubMed Journal: Arch Endocrinol Metab ISSN： 2359-3997 Impact factor: 2.309