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Literature DB >> 31939176

Detection of Ferroptosis by BODIPY™ 581/591 C11.

Alejandra M Martinez¹, Ahryun Kim¹, Wan Seok Yang².

Abstract

Ferroptosis is a distinctive form of regulated cell death that is driven by lethal accumulation of lipid peroxides in plasma membranes. Failure to control ferroptosis has been implicated in multiple pathological conditions including cancer development, neurodegeneration, renal injury, ischemia/reperfusion injury, and T-cell immunity. Here we describe a method to detect ferroptosis by determining the amount of lipid peroxides in cellular membranes using BODIPY-C11 probe and flow cytometry. Putative role of ferroptosis in immune modulatory cells can be determined using the same method.

Entities: Chemical

Keywords: BODIPY-C11; Erastin; Ferroptosis; Flow cytometry; Lipid peroxides

Mesh：

Substances：

Year: 2020 PMID： 31939176 DOI： 10.1007/978-1-0716-0247-8_11

Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745

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Cited

14 in total

1. Loss of PPR protein Ppr2 induces ferroptosis-like cell death in Schizosaccharomyces pombe.

Authors: Zecheng Liu; Alia Ebrahim; Xiaoyu Wu; Minjie Li; Ying Huang
Journal: Arch Microbiol Date: 2022-06-03 Impact factor: 2.552

2. AUF1 protects against ferroptosis to alleviate sepsis-induced acute lung injury by regulating NRF2 and ATF3.

Authors: Yichun Wang; Diyu Chen; Han Xie; Mingwang Jia; Xiaofang Sun; Fang Peng; Feifei Guo; Daolin Tang
Journal: Cell Mol Life Sci Date: 2022-04-07 Impact factor: 9.261

3. Targeting ferroptosis with miR-144-3p to attenuate pancreatic β cells dysfunction via regulating USP22/SIRT1 in type 2 diabetes.

Authors: Shanshan Zhang; Xiao Liu; Jihong Wang; Fengjuan Yuan; Yali Liu
Journal: Diabetol Metab Syndr Date: 2022-06-27 Impact factor: 5.395

4. Metabolic stress induces GD2⁺ cancer stem cell-like phenotype in triple-negative breast cancer.

Authors: Appalaraju Jaggupilli; Stanley Ly; Khoa Nguyen; Vivek Anand; Bin Yuan; Fouad El-Dana; Yuanqing Yan; Zoe Arvanitis; Danthasinghe Waduge Badrajee Piyarathna; Nagireddy Putluri; Helen Piwnica-Worms; Henry Charles Manning; Michael Andreeff; V Lokesh Battula
Journal: Br J Cancer Date: 2021-11-22 Impact factor: 9.075

5. PARP inhibition promotes ferroptosis via repressing SLC7A11 and synergizes with ferroptosis inducers in BRCA-proficient ovarian cancer.

Authors: Ting Hong; Guang Lei; Xue Chen; He Li; Xiaoye Zhang; Nayiyuan Wu; Yu Zhao; Yilei Zhang; Jing Wang
Journal: Redox Biol Date: 2021-03-05 Impact factor: 11.799

Detection of Ferroptosis by BODIPY™ 581/591 C11.

1. Loss of PPR protein Ppr2 induces ferroptosis-like cell death in Schizosaccharomyces pombe.

2. AUF1 protects against ferroptosis to alleviate sepsis-induced acute lung injury by regulating NRF2 and ATF3.

3. Targeting ferroptosis with miR-144-3p to attenuate pancreatic β cells dysfunction via regulating USP22/SIRT1 in type 2 diabetes.

4. Metabolic stress induces GD2⁺ cancer stem cell-like phenotype in triple-negative breast cancer.

5. PARP inhibition promotes ferroptosis via repressing SLC7A11 and synergizes with ferroptosis inducers in BRCA-proficient ovarian cancer.

6. Iron Administration Overcomes Resistance to Erastin-Mediated Ferroptosis in Ovarian Cancer Cells.

Review 7. Ferroptosis and Cancer: Mitochondria Meet the "Iron Maiden" Cell Death.

8. Chemotoxicity-induced exosomal lncFERO regulates ferroptosis and stemness in gastric cancer stem cells.

Review 9. Targeting ferroptosis in acute kidney injury.

Review 10. Programmed cell death, redox imbalance, and cancer therapeutics.