Yushu Chen1, Wen Zeng2, Wei Chen1,3, Yu Zhang1, Tong Zhu1, Jiayu Sun1, Zhigang Liang2, Lei Wang1, Zunyuan Yang2, Bing Wu1, Bin Song1, Fangtong Wang2, Yinan Liang2, Li Gong2, Jie Zheng4, Fabao Gao5,6. 1. Department of Radiology, Sichuan University West China Hospital, 37 Guoxuexiang, Chengdu, 610041, Sichuan, China. 2. Sichuan Primed Shines Biotech Co., Ltd., Chengdu, China. 3. Department of Radiology, First Affiliated Hospital of Kunming Medical University, Kunming, China. 4. Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA. 5. Department of Radiology, Sichuan University West China Hospital, 37 Guoxuexiang, Chengdu, 610041, Sichuan, China. gaofabao@wchscu.cn. 6. Sichuan Primed Shines Biotech Co., Ltd., Chengdu, China. gaofabao@wchscu.cn.
Abstract
AIMS: To investigate the correlation of impairment in skeletal muscle and heart in spontaneous type 2 diabetes mellitus (T2DM) rhesus monkeys using magnetic resonance image (MRI). METHODS: Fifteen T2DM monkeys and fourteen healthy control (HC) monkeys were included. The microcirculation of skeletal muscle [skeletal muscle blood flow (SMBF), skeletal muscle oxygen extraction fraction (SMOEF)] and the function and strain of heart were evaluated by MRI. Three regions of interests were chosen on the soleus muscle (SOL), gastrocnemius muscle (GAS) and tibialis anterior muscle (TA) for image analysis. RESULTS: Eight T2DM monkeys and eight HC monkeys were obtained the full data. The SMBF reserves and SMOEF reserves were found significantly decreased in T2DM during inflation in SOL, GAS and TA muscles (all p < 0.05), and the SMBF reserves decreased during hyperemia in GAS and TA muscles (all p < 0.05). In these monkeys, the global peak longitudinal strain (longitudinal PS), peak systolic longitudinal strain rate (longitudinal PSSR) and peak diastolic longitudinal strain rate (longitudinal PDSR) were seen significantly different in T2DM compared to HC monkeys (all p < 0.05). The longitudinal PSSR was found negatively correlated with SMBF reserves in SOL, GAS and TA during inflation in all monkeys. CONCLUSIONS: The impaired microcirculation of skeletal muscle and the myocardial deformation were found in T2DM monkeys with normal ejection fraction. And a negative correlation was existed in the longitudinal PSSR and the SMBF reserves.
AIMS: To investigate the correlation of impairment in skeletal muscle and heart in spontaneous type 2 diabetes mellitus (T2DM) rhesus monkeys using magnetic resonance image (MRI). METHODS: Fifteen T2DM monkeys and fourteen healthy control (HC) monkeys were included. The microcirculation of skeletal muscle [skeletal muscle blood flow (SMBF), skeletal muscle oxygen extraction fraction (SMOEF)] and the function and strain of heart were evaluated by MRI. Three regions of interests were chosen on the soleus muscle (SOL), gastrocnemius muscle (GAS) and tibialis anterior muscle (TA) for image analysis. RESULTS: Eight T2DM monkeys and eight HC monkeys were obtained the full data. The SMBF reserves and SMOEF reserves were found significantly decreased in T2DM during inflation in SOL, GAS and TA muscles (all p < 0.05), and the SMBF reserves decreased during hyperemia in GAS and TA muscles (all p < 0.05). In these monkeys, the global peak longitudinal strain (longitudinal PS), peak systolic longitudinal strain rate (longitudinal PSSR) and peak diastolic longitudinal strain rate (longitudinal PDSR) were seen significantly different in T2DM compared to HC monkeys (all p < 0.05). The longitudinal PSSR was found negatively correlated with SMBF reserves in SOL, GAS and TA during inflation in all monkeys. CONCLUSIONS: The impaired microcirculation of skeletal muscle and the myocardial deformation were found in T2DM monkeys with normal ejection fraction. And a negative correlation was existed in the longitudinal PSSR and the SMBF reserves.
Authors: Daniel M Hirai; Steven W Copp; Clark T Holdsworth; Scott K Ferguson; Danielle J McCullough; Bradley J Behnke; Timothy I Musch; David C Poole Journal: Am J Physiol Heart Circ Physiol Date: 2014-01-10 Impact factor: 4.733
Authors: Gregory A Nichols; Christina M Gullion; Carol E Koro; Sara A Ephross; Jonathan B Brown Journal: Diabetes Care Date: 2004-08 Impact factor: 19.112