Literature DB >> 31938600

Sarcomatous Transformation of Recurrent Scapular Osteochondroma in a Patient with the Hereditary Multiple Osteochondromas: A Case Report and Literature Review.

Sadia Sajid1, Amman Yousaf2, Usman Nabi1, Amir Shahbaz3, Umar Amin4.   

Abstract

Hereditary multiple osteochondromas (HMO) is an autosomal dominant disease diagnosed by the presence of two or more than two osteochondromas on radiographs. The majority of cases are asymptomatic. The presence of bony growth, pain, and compression of the surrounding structure are the usual presentations. Malignant transformation into chondrosarcoma is the most feared complication. A rapid increase in size, recurrence after the surgical excision, and infiltrating mass may suggest the conversion into chondrosarcoma. Radiological imaging helps in diagnosing malignant transformation. MRI is the investigation of choice to exclude cancer. We hereby present a case of multiple osteochondromas with suspected malignant transformation due to rapidly increasing painful osseous swelling.
Copyright © 2019, Sajid et al.

Entities:  

Keywords:  autosomal dominant; chondrosarcoma; hereditory multiple exostoses; osteochondroma; prognostic factors; role of diagnostic imaging; scapular tumor; secondary osseous malignancy; surgical excision; tumor suppressor genes

Year:  2019        PMID: 31938600      PMCID: PMC6944176          DOI: 10.7759/cureus.6308

Source DB:  PubMed          Journal:  Cureus        ISSN: 2168-8184


  16 in total

Review 1.  Imaging the complications of osteochondromas.

Authors:  K C Y Lee; A M Davies; V N Cassar-Pullicino
Journal:  Clin Radiol       Date:  2002-01       Impact factor: 2.350

2.  Joint pain in hereditary multiple exostoses.

Authors:  David J Bruce; Duncan Whitwell; Hemant Pandit
Journal:  BMJ       Date:  2015-02-11

3.  Intraosseous atypical chondroid tumor or chondrosarcoma grade 1 in patients with multiple osteochondromas.

Authors:  Annemarie L Goud; Wim Wuyts; Johannes Bessems; Jos Bramer; Henk Jan van der Woude; John Ham
Journal:  J Bone Joint Surg Am       Date:  2015-01-07       Impact factor: 5.284

Review 4.  Hereditary Multiple Exostoses: a review of clinical appearance and metabolic pattern.

Authors:  Giovanni Beltrami; Gabriele Ristori; Guido Scoccianti; Angela Tamburini; Rodolfo Capanna
Journal:  Clin Cases Miner Bone Metab       Date:  2016-10-05

5.  Thoracic cord compression due to chondrosarcoma in two cousins with hereditary multiple exostoses. Report of two cases.

Authors:  R M Crowell; J G Wepsic
Journal:  J Neurosurg       Date:  1972-01       Impact factor: 5.115

Review 6.  Whole-body MRI in assessing malignant transformation in multiple hereditary exostoses and enchondromatosis: audit results and literature review.

Authors:  Anne Grethe Jurik; Peter Holmberg Jørgensen; Mikkel Meng Mortensen
Journal:  Skeletal Radiol       Date:  2019-07-05       Impact factor: 2.199

7.  Multiple osteocartilaginous exostoses of the lower extremity: a case report.

Authors:  Garry Shtofmakher; Michelle A Kaufman; Prashant H Bhoola; Ankur A Patel; Susan M Rice; Randy E Cohen
Journal:  Foot (Edinb)       Date:  2014-12-08

8.  Secondary Chondrosarcoma of the Lumbosacral Region: Are any Bones Spared in the Multiple Hereditary Exostoses?

Authors:  Hemalatha Anantharamaiah; R Kalyani; Harendra Kumar M L; Manohar P V
Journal:  J Clin Diagn Res       Date:  2012-12-15

Review 9.  Hereditary multiple exostoses and enchondromatosis.

Authors:  Stéphanie Pannier; Laurence Legeai-Mallet
Journal:  Best Pract Res Clin Rheumatol       Date:  2008-03       Impact factor: 4.098

10.  Chondrosarcoma transformation in hereditary multiple exostoses: A systematic review and clinical and cost-effectiveness of a proposed screening model.

Authors:  Li Fei; Clara Ngoh; Daniel E Porter
Journal:  J Bone Oncol       Date:  2018-10-04       Impact factor: 4.072

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  1 in total

Review 1.  An unusual example of hereditary multiple exostoses: a case report and review of the literature.

Authors:  Rebecca Chilvers; James A Gallagher; Nathan Jeffery; Alistair P Bond
Journal:  BMC Musculoskelet Disord       Date:  2021-01-21       Impact factor: 2.362

  1 in total

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