Literature DB >> 31938218

Knockdown of long non-coding RNA AFAP1-AS1 inhibits growth and promotes apoptosis in pituitary adenomas.

Hengxin Tang1, Bo Hou1, Zhuopeng Ye1, Cong Ling1, Ying Guo1.   

Abstract

Recent studies have reported that the long non-coding RNA (lncRNA) AFAP antisense RNA 1 (AFAP1-AS1) is involved in various biological processes and plays a key role in regulating cancer growth and metastasis in humans. However, its effects on tumorigenesis in pituitary adenomas remain unclear. The present study investigated the expression and biological role of AFAP1-AS1 in pituitary adenomas. We observed that the expression of AFAP1-AS1 was considerably higher in the pituitary adenoma tissues as compared to its expression in the adjacent tissues. Additionally, knockdown of AFAP1-AS1 inhibited the proliferation, arrested the cell cycle in the G1-to-S transition phase, and promoted apoptosis in GH3 and MMQ cells. Finally, knockdown of AFAP1-AS1 also promoted the expression of PTEN and inhibited the expression of PI3K and p-AKT. Our results provided novel insights into the function and mechanism of action of AFAP1-AS1 in the pathogenesis of pituitary adenomas. IJCEP
Copyright © 2018.

Entities:  

Keywords:  AFAP1-AS1; Long non-coding RNA; PTEN/PI3K/AKT; pituitary adenoma

Year:  2018        PMID： 31938218      PMCID： PMC6958144     

Source DB:  PubMed          Journal:  Int J Clin Exp Pathol        ISSN： 1936-2625


  23 in total

1.  Endoscopic transsphenoidal approach to pituitary adenomas invading the cavernous sinus.

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2.  Long noncoding RNA AFAP1-AS1 indicates a poor prognosis of hepatocellular carcinoma and promotes cell proliferation and invasion via upregulation of the RhoA/Rac2 signaling.

Authors:  Jin-Yan Zhang; Ming-Zhe Weng; Fang-Bin Song; Yong-Gang Xu; Qi Liu; Jun-Yi Wu; Jun Qin; Tao Jin; Jun-Ming Xu
Journal:  Int J Oncol       Date:  2016-02-08       Impact factor: 5.650

3.  Long Noncoding RNA AFAP1-AS1 Promoted Tumor Growth and Invasion in Cholangiocarcinoma.

Authors:  Xu Lu; Chuang Zhou; Renfeng Li; Yilei Deng; Longshuan Zhao; Wenlong Zhai
Journal:  Cell Physiol Biochem       Date:  2017-05-25

4.  Outcome of Nonfunctioning Pituitary Adenomas That Regrow After Primary Treatment: A Study From Two Large UK Centers.

Authors:  Metaxia Tampourlou; Georgia Ntali; Shahzada Ahmed; Wiebke Arlt; John Ayuk; James V Byrne; Swarupsinh Chavda; Simon Cudlip; Neil Gittoes; Ashley Grossman; Rosalind Mitchell; Michael W O'Reilly; Alessandro Paluzzi; Andrew Toogood; John A H Wass; Niki Karavitaki
Journal:  J Clin Endocrinol Metab       Date:  2017-06-01       Impact factor: 5.958

5.  Long non-coding RNA HOXA11-AS functions as a competing endogenous RNA to regulate ROCK1 expression by sponging miR-124-3p in osteosarcoma.

Authors:  Mingxing Cui; Jingyu Wang; Qingjiang Li; Junlei Zhang; Jinling Jia; Xinli Zhan
Journal:  Biomed Pharmacother       Date:  2017-05-27       Impact factor: 6.529

6.  Long Noncoding RNA AFAP1-AS1 Promotes Cell Proliferation and Apoptosis of Gastric Cancer Cells via PTEN/p-AKT Pathway.

Authors:  Jun-Qiang Guo; Shi-Jie Li; Guo-Xiao Guo
Journal:  Dig Dis Sci       Date:  2017-04-27       Impact factor: 3.199

7.  Metalloproteinases ADAM12 and MMP-14 are associated with cavernous sinus invasion in pituitary adenomas.

Authors:  Junwen Wang; Benjamin Voellger; Julia Benzel; Uwe Schlomann; Christopher Nimsky; Jörg W Bartsch; Barbara Carl
Journal:  Int J Cancer       Date:  2016-05-24       Impact factor: 7.396

8.  Incidence and prevalence of clinically relevant pituitary adenomas: retrospective cohort study in a Health Management Organization in Buenos Aires, Argentina.

Authors:  Patricia Fainstein Day; Monica Graciela Loto; Mariela Glerean; María Fabiana Russo Picasso; Soledad Lovazzano; Diego Hernán Giunta
Journal:  Arch Endocrinol Metab       Date:  2016-08-25       Impact factor: 2.309

Review 9.  Advancements in the study of miRNA regulation during the cell cycle in human pituitary adenomas.

Authors:  Ting Zhang; Zijiang Yang; Heng Gao
Journal:  J Neurooncol       Date:  2017-06-02       Impact factor: 4.130

10.  Co-expression of AFAP1-AS1 and PD-1 predicts poor prognosis in nasopharyngeal carcinoma.

Authors:  Yanyan Tang; Yi He; Lei Shi; Liting Yang; Jinpeng Wang; Yu Lian; Chunmei Fan; Ping Zhang; Can Guo; Shanshan Zhang; Zhaojian Gong; Xiayu Li; Fang Xiong; Xiaoling Li; Yong Li; Guiyuan Li; Wei Xiong; Zhaoyang Zeng
Journal:  Oncotarget       Date:  2017-06-13
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  5 in total

1.  PI3K inhibition by BKM120 results in anti-proliferative effects on corticotroph tumor cells.

Authors:  H A Oliveira; A C Bueno; R S Pugliesi; R M P da Silva Júnior; M de Castro; C S Martins
Journal:  J Endocrinol Invest       Date:  2022-01-06       Impact factor: 4.256

2.  LncRNA PCAT6 regulates the progression of pituitary adenomas by regulating the miR-139-3p/BRD4 axis.

Authors:  Peng Zhao; Jianhua Cheng; Bin Li; Ding Nie; Hongyun Wang; Chuzhong Li; Songbai Gui; Yazhuo Zhang
Journal:  Cancer Cell Int       Date:  2021-01-06       Impact factor: 5.722

Review 3.  A Review on the Role of AFAP1-AS1 in the Pathoetiology of Cancer.

Authors:  Soudeh Ghafouri-Fard; Tayybeh Khoshbakht; Bashdar Mahmud Hussen; Mohammad Taheri; Majid Mokhtari
Journal:  Front Oncol       Date:  2021-11-29       Impact factor: 6.244

Review 4.  The Emerging Role of Non-Coding RNAs in Pituitary Gland Tumors and Meningioma.

Authors:  Soudeh Ghafouri-Fard; Atefe Abak; Bashdar Mahmud Hussen; Mohammad Taheri; Guive Sharifi
Journal:  Cancers (Basel)       Date:  2021-11-28       Impact factor: 6.639

Review 5.  Novel Insights into Pituitary Tumorigenesis: Genetic and Epigenetic Mechanisms.

Authors:  Vinaya Srirangam Nadhamuni; Márta Korbonits
Journal:  Endocr Rev       Date:  2020-12-01       Impact factor: 19.871
  5 in total

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