| Literature DB >> 3193492 |
D Perrot1, B Bui-Xuan, J Lang, Y Bouffard, B Delafosse, G Faucon, J Motin.
Abstract
The case of a 58 year old woman who died after ingestion of 14.4 g of sotalol and 50 mg of triazolam is described. Despite medical treatment, intracardiac pacing and hemodialysis, cardiovascular failure persisted and became irreversible. High sotalol concentrations were observed in plasma (65 micrograms/ml) and in post mortem tissues samples. Tissue to plasma ratios ranged from 2.5 to 6. The high drug concentration found in heart tissue (104.4 micrograms/g) explains the difficulties experienced in the sotalol poisoning.Entities:
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Year: 1988 PMID： 3193492 DOI： 10.1080/15563658809167103
Source DB: PubMed Journal: J Toxicol Clin Toxicol ISSN： 0731-3810