Minghua Cui1,2, Quanzhu Chen1,2, Chaojun He3, Nan Wang4, Yong Yu1,2, Ziyang Sun1,2, Zhenhua Lin1,2, Hesong Cui5, Shengyu Jin6, Jae Yong Park7, Guang Jin1,2, Shin Yup Lee7, Qingsong Cui8. 1. Key Laboratory of The Science and Technology Department of Jilin Province Yanji, Jilin, China. 2. Department of Pathology & Cancer Research Center, Yanbian University Medical College Yanji, Jilin, China. 3. Chengdu Second People's Hospital of Sichuan Province, Breast and Vascular Surgery Chengdu, Sichuan, China. 4. Department of Pathology, Shenyang 242 Hospital Shenyang, Liaoning, China. 5. Department of Infections, Yanbian University Hospital Yanji, Jilin, China. 6. Department of Hematology, Yanbian University Hospital Yanji, Jilin, China. 7. Department of Internal Medicine, School of Medicine, Kyungpook National University Daegu, Republic of Korea. 8. Department of Intensive Care Unit, Yanbian University Hospital Yanji, Jilin, China.
Abstract
BACKGROUND & AIMS: Primary hepatic cancer (PHC) is a common malignant tumor and the third most frequent cause of cancer-related death worldwide. However, the molecular mechanisms underlying hepatic cancer remain unknown. CTSB is considered a biomarker of cancer as it can facilitate tumor progression. We aimed to investigate the association between genetic polymorphisms of potential regulatory SNPs in the CTSB gene and PHC. METHODS: The relationship between CTSB rs12898 and PHC was analyzed in a case-control study with a Chinese population of 608 PHC patients and 608 healthy individuals using SPSS 21.0. RESULTS: PHC was significantly associated with alcohol consumption (P < 0.001), history of hepatitis (P < 0.001), and liver cirrhosis (P < 0.001), but not with smoking (P = 0.168), age (P = 0.175), or sex (P = 0.051). Distribution of three genotypes (GG, GA, and AA) of CTSB rs12898 significantly differed between the cases and controls (P < 0.001). Compared with the GG genotype, the GA and AA genotype was associated with a significantly increased risk of PHC (OR = 1.425, 95% CI = 1.099-1.848, P = 0.007; and OR = 2.220, 95% CI = 1.574-3.132, P < 0.001, respectively). CTSB rs12898 was associated with a significantly increased risk of PHC under a dominant model (OR = 1.592, 95% CI = 1.243-2.040, P < 0.001), and under a recessive model (OR = 1.771, 95% CI = 1.311-2.393, P < 0.001) for the variant A allele. CONCLUSION: Results suggest that CTSB rs12898G > A may play a role in the pathogenesis of PHC, and may be a marker for susceptibility to PHC. IJCEP
BACKGROUND & AIMS:Primary hepatic cancer (PHC) is a common malignant tumor and the third most frequent cause of cancer-related death worldwide. However, the molecular mechanisms underlying hepatic cancer remain unknown. CTSB is considered a biomarker of cancer as it can facilitate tumor progression. We aimed to investigate the association between genetic polymorphisms of potential regulatory SNPs in the CTSB gene and PHC. METHODS: The relationship between CTSBrs12898 and PHC was analyzed in a case-control study with a Chinese population of 608 PHCpatients and 608 healthy individuals using SPSS 21.0. RESULTS:PHC was significantly associated with alcohol consumption (P < 0.001), history of hepatitis (P < 0.001), and liver cirrhosis (P < 0.001), but not with smoking (P = 0.168), age (P = 0.175), or sex (P = 0.051). Distribution of three genotypes (GG, GA, and AA) of CTSBrs12898 significantly differed between the cases and controls (P < 0.001). Compared with the GG genotype, the GA and AA genotype was associated with a significantly increased risk of PHC (OR = 1.425, 95% CI = 1.099-1.848, P = 0.007; and OR = 2.220, 95% CI = 1.574-3.132, P < 0.001, respectively). CTSBrs12898 was associated with a significantly increased risk of PHC under a dominant model (OR = 1.592, 95% CI = 1.243-2.040, P < 0.001), and under a recessive model (OR = 1.771, 95% CI = 1.311-2.393, P < 0.001) for the variant A allele. CONCLUSION: Results suggest that CTSB rs12898G > A may play a role in the pathogenesis of PHC, and may be a marker for susceptibility to PHC. IJCEP
Authors: Julius Balogh; David Victor; Emad H Asham; Sherilyn Gordon Burroughs; Maha Boktour; Ashish Saharia; Xian Li; R Mark Ghobrial; Howard P Monsour Journal: J Hepatocell Carcinoma Date: 2016-10-05