Shaofeng Lin1,2, Menghan Zhou3,4, Yiping Li5, Yanping Chen6, Weizhang Xu1, Wenjia Xia1, Siwei Wang1, Rong Yin1, Qin Zhang1, Lin Xu1, Hong Fan3. 1. Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital and Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research, Jiangsu Key Laboratory of Molecular and Translational Cancer Research Nanjing 210009, China. 2. Department of Thoracic Surgery, Fujian Cancer Hospital and Fujian Medical University Cancer Hospital and Fujian Provincial Key Laboratory of Tumor Biotherapy Fuzhou 350014, China. 3. Department of Medical Genetics and Developmental Biology, Medical School of Southeast University, The Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Southeast University Nanjing 210009, China. 4. Institute of Life Sciences, The Key Laboratory of Developmental Genes and Human Disease, Southeast University Nanjing 210018, China. 5. Department of Pathology, Medical School, Southeast University Nanjing 210009, China. 6. Department of Pathology, Fujian Cancer Hospital and Fujian Medical University Cancer Hospital Fuzhou 350014, China.
Abstract
BACKGROUND: Esophageal cancer (EC) is the fourth most commonly diagnosed cancer in males and the fifth in females in China. Dysregulation methylation of histone is now considered a biomarker for cancer prognosis. METHODS: In this study, we focused on exploring the expression patterns of two repressor histone methylation marks, H3K9 dimethylation (H3K9me2) and H3K27 trimethylation (H3K27me3), to provide potential biomarkers for diagnosis and therapies in esophageal squamous cell carcinoma (ESCC). RESULTS: After analyzing the relationship between the expression pattern of H3K27me3 and the clinic-pathological features of ESCC tissues, we found that upregulated H3K27me3 correlated with advanced T stage and N stage. A multivariate Cox regression analysis showed H3K27me3 expression, T stage and N stage were all independent factors for the poor prognosis of ESCC. Therefore, H3K27me3 can be considered an independent factor for predicting the prognosis of ESCC. CONCLUSIONS: Chromatin remodeling, especially the methylation of H3, plays a vital role in ESCC development and is a potential therapeutic target. IJCEP
BACKGROUND:Esophageal cancer (EC) is the fourth most commonly diagnosed cancer in males and the fifth in females in China. Dysregulation methylation of histone is now considered a biomarker for cancer prognosis. METHODS: In this study, we focused on exploring the expression patterns of two repressor histone methylation marks, H3K9 dimethylation (H3K9me2) and H3K27 trimethylation (H3K27me3), to provide potential biomarkers for diagnosis and therapies in esophageal squamous cell carcinoma (ESCC). RESULTS: After analyzing the relationship between the expression pattern of H3K27me3 and the clinic-pathological features of ESCC tissues, we found that upregulated H3K27me3 correlated with advanced T stage and N stage. A multivariate Cox regression analysis showed H3K27me3 expression, T stage and N stage were all independent factors for the poor prognosis of ESCC. Therefore, H3K27me3 can be considered an independent factor for predicting the prognosis of ESCC. CONCLUSIONS: Chromatin remodeling, especially the methylation of H3, plays a vital role in ESCC development and is a potential therapeutic target. IJCEP