Literature DB >> 31932468

Posttranslational Regulation and Conformational Plasticity of PTEN.

Larissa Kotelevets1,2, Barbara Trifault3,4,5, Eric Chastre1,2, Mark G H Scott3,4,5.   

Abstract

Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a tumor suppressor that is frequently down-modulated in human cancer. PTEN inhibits the phosphatidylinositol 3-phosphate kinase (PI3K)/AKT pathway through its lipid phosphatase activity. Multiple PI3K/AKT-independent actions of PTEN, protein-phosphatase activities and functions within the nucleus have also been described. PTEN, therefore, regulates many cellular processes including cell proliferation, survival, genomic integrity, polarity, migration, and invasion. Even a modest decrease in the functional dose of PTEN may promote cancer development. Understanding the molecular and cellular mechanisms that regulate PTEN protein levels and function, and how these may go awry in cancer contexts, is, therefore, key to fully understanding the role of PTEN in tumorigenesis. Here, we discuss current knowledge on posttranslational control and conformational plasticity of PTEN, as well as therapeutic possibilities toward reestablishment of PTEN tumor-suppressor activity in cancer.
Copyright © 2020 Cold Spring Harbor Laboratory Press; all rights reserved.

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Year:  2020        PMID： 31932468      PMCID： PMC7328454          DOI： 10.1101/cshperspect.a036095

Source DB:  PubMed          Journal:  Cold Spring Harb Perspect Med        ISSN： 2157-1422            Impact factor:   5.159


  130 in total

1.  Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2.

Authors:  Thomas Mund; Hugh R B Pelham
Journal:  Proc Natl Acad Sci U S A       Date:  2010-06-07       Impact factor: 11.205

2.  Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway.

Authors:  Jonathan D Lee; Jinfang Zhang; Shu-Yu Lin; Yu-Ru Lee; Ming Chen; Tian-Min Fu; Hao Chen; Tomoki Ishikawa; Shang-Yin Chiang; Jesse Katon; Yang Zhang; Yulia V Shulga; Assaf C Bester; Jacqueline Fung; Emanuele Monteleone; Lixin Wan; Chen Shen; Chih-Hung Hsu; Antonella Papa; John G Clohessy; Julie Teruya-Feldstein; Suresh Jain; Hao Wu; Lydia Matesic; Ruey-Hwa Chen; Wenyi Wei; Pier Paolo Pandolfi
Journal:  Science       Date:  2019-05-17       Impact factor: 47.728

3.  Ordered phosphorylation events in two independent cascades of the PTEN C-tail revealed by NMR.

Authors:  Florence Cordier; Alain Chaffotte; Elouan Terrien; Christophe Préhaud; François-Xavier Theillet; Muriel Delepierre; Monique Lafon; Henri Buc; Nicolas Wolff
Journal:  J Am Chem Soc       Date:  2012-12-07       Impact factor: 15.419

4.  Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair.

Authors:  Jianhui Ma; Jorge A Benitez; Jie Li; Shunichiro Miki; Claudio Ponte de Albuquerque; Thais Galatro; Laura Orellana; Ciro Zanca; Rachel Reed; Antonia Boyer; Tomoyuki Koga; Nissi M Varki; Tim R Fenton; Suely Kazue Nagahashi Marie; Erik Lindahl; Timothy C Gahman; Andrew K Shiau; Huilin Zhou; John DeGroot; Erik P Sulman; Webster K Cavenee; Richard D Kolodner; Clark C Chen; Frank B Furnari
Journal:  Cancer Cell       Date:  2019-02-28       Impact factor: 31.743

5.  LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes.

Authors:  Hamid Mehenni; Nathalie Lin-Marq; Karine Buchet-Poyau; Alexandre Reymond; Martine A Collart; Didier Picard; Stylianos E Antonarakis
Journal:  Hum Mol Genet       Date:  2005-06-29       Impact factor: 6.150

6.  Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3beta.

Authors:  Anna Maria Al-Khouri; Yuliang Ma; Summanuna H Togo; Scott Williams; Tomas Mustelin
Journal:  J Biol Chem       Date:  2005-08-17       Impact factor: 5.157

7.  Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN.

Authors:  V Stambolic; A Suzuki; J L de la Pompa; G M Brothers; C Mirtsos; T Sasaki; J Ruland; J M Penninger; D P Siderovski; T W Mak
Journal:  Cell       Date:  1998-10-02       Impact factor: 41.582

8.  Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a.

Authors:  Barry Fine; Cindy Hodakoski; Susan Koujak; Tao Su; Lao H Saal; Matthew Maurer; Benjamin Hopkins; Megan Keniry; Maria Luisa Sulis; Sarah Mense; Hanina Hibshoosh; Ramon Parsons
Journal:  Science       Date:  2009-09-04       Impact factor: 47.728

9.  The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein.

Authors:  Muhan Chen; Dawid G Nowak; Navneet Narula; Brian Robinson; Kaitlin Watrud; Alexandra Ambrico; Tali M Herzka; Martha E Zeeman; Matthias Minderer; Wu Zheng; Saya H Ebbesen; Kendra S Plafker; Carlos Stahlhut; Victoria M Y Wang; Lorna Wills; Abu Nasar; Mireia Castillo-Martin; Carlos Cordon-Cardo; John E Wilkinson; Scott Powers; Raffaella Sordella; Nasser K Altorki; Vivek Mittal; Brendon M Stiles; Scott M Plafker; Lloyd C Trotman
Journal:  J Cell Biol       Date:  2017-02-13       Impact factor: 10.539

10.  Regulation of the PI3K pathway through a p85α monomer-homodimer equilibrium.

Authors:  Lydia W T Cheung; Katarzyna W Walkiewicz; Tabot M D Besong; Huifang Guo; David H Hawke; Stefan T Arold; Gordon B Mills
Journal:  Elife       Date:  2015-07-29       Impact factor: 8.140
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  10 in total

Review 1.  The biochemical and clinical implications of phosphatase and tensin homolog deleted on chromosome ten in different cancers.

Authors:  Qinyi Wang; Junmin Wang; Hongjiao Xiang; Peilun Ding; Tao Wu; Guang Ji
Journal:  Am J Cancer Res       Date:  2021-12-15       Impact factor: 6.166

Review 2.  PTEN: An Emerging Potential Target for Therapeutic Intervention in Respiratory Diseases.

Authors:  Bangrong Cai; Liu Yang; Young Do Jung; Ying Zhang; Xinguang Liu; Peng Zhao; Jiansheng Li
Journal:  Oxid Med Cell Longev       Date:  2022-06-30       Impact factor: 7.310

Review 3.  Allostery: Allosteric Cancer Drivers and Innovative Allosteric Drugs.

Authors:  Ruth Nussinov; Mingzhen Zhang; Ryan Maloney; Yonglan Liu; Chung-Jung Tsai; Hyunbum Jang
Journal:  J Mol Biol       Date:  2022-04-01       Impact factor: 6.151

Review 4.  Phosphorylation and Driver Mutations in PI3Kα and PTEN Autoinhibition.

Authors:  Ruth Nussinov; Mingzhen Zhang; Chung-Jung Tsai; Hyunbum Jang
Journal:  Mol Cancer Res       Date:  2020-12-07       Impact factor: 6.333

5.  Fluctuations in AKT and PTEN Activity Are Linked by the E3 Ubiquitin Ligase cCBL.

Authors:  Manuel Olazábal-Morán; Miriam Sánchez-Ortega; Laura Martínez-Muñoz; Carmen Hernández; Manuel S Rodríguez; Mario Mellado; Ana C Carrera
Journal:  Cells       Date:  2021-10-20       Impact factor: 6.600

Review 6.  The Role of PTEN in Epithelial-Mesenchymal Transition.

Authors:  Olga Fedorova; Sergey Parfenyev; Alexandra Daks; Oleg Shuvalov; Nickolai A Barlev
Journal:  Cancers (Basel)       Date:  2022-08-03       Impact factor: 6.575

Review 7.  PTEN Dual Lipid- and Protein-Phosphatase Function in Tumor Progression.

Authors:  Anne Liu; Yanyu Zhu; Weiping Chen; Glenn Merlino; Yanlin Yu
Journal:  Cancers (Basel)       Date:  2022-07-28       Impact factor: 6.575

8.  Circulating Extracellular Vesicles and Particles Derived From Adipocytes: The Potential Role in Spreading MicroRNAs Associated With Cellular Senescence.

Authors:  Ionara Rodrigues Siqueira; Andressa de Souza Rodrigues; Marina Siqueira Flores; Eduarda Letícia Vieira Cunha; Madeleine Goldberg; Brennan Harmon; Rachael Batabyal; Robert J Freishtat; Laura Reck Cechinel
Journal:  Front Aging       Date:  2022-08-09

9.  The role of PTEN in puromycin aminonucleoside-induced podocyte injury.

Authors:  Qi Ren; Shengyou Yu; Huasong Zeng; Huimin Xia
Journal:  Int J Med Sci       Date:  2022-08-15       Impact factor: 3.642

10.  The mechanism of full activation of tumor suppressor PTEN at the phosphoinositide-enriched membrane.

Authors:  Hyunbum Jang; Iris Nira Smith; Charis Eng; Ruth Nussinov
Journal:  iScience       Date:  2021-04-17
  10 in total

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