Literature DB >> 31930094

The potential roles of stem cell-derived extracellular vesicles as a therapeutic tool.

Yu-Chin Huang1,2, Liang-Chuan Lai1,3.   

Abstract

Extracellular vesicles (EVs) of mesenchymal stem cells (MSCs) are secreted by live cells and possess the same regenerative potential and immunomodulatory ability as their parental cells. Clinical applications of MSC-EVs could overcome the shortage of MSCs for treatment of cancer and other diseases and impact the field of regenerative medicine from cellular to acellular therapy. For use of MSC-EVs as a clinical agent, various engineered EVs have been manufactured and their therapeutic effects on various diseases demonstrated in preclinical studies and clinical trials. However, MSC-EVs are heterogeneous, and many of their characteristics are still unknown. Many barriers still need to be surmounted before MSC-EVs can be used as biomedical agents. 2019 Annals of Translational Medicine. All rights reserved.

Entities:  

Keywords:  Mesenchymal stem cell (MSC); extracellular vesicle (EV); therapeutic tool

Year:  2019        PMID： 31930094      PMCID： PMC6944607          DOI： 10.21037/atm.2019.11.66

Source DB:  PubMed          Journal:  Ann Transl Med        ISSN： 2305-5839


  8 in total

1.  miR-18a-5p derived from mesenchymal stem cells-extracellular vesicles inhibits ovarian cancer cell proliferation, migration, invasion, and chemotherapy resistance.

Authors:  Xiaoying Wang; Lili Jiang; Qifang Liu
Journal:  J Transl Med       Date:  2022-06-07       Impact factor: 8.440

2.  Extracellular vesicles from skin precursor-derived Schwann cells promote axonal outgrowth and regeneration of motoneurons via Akt/mTOR/p70S6K pathway.

Authors:  Xia Wu; Liting Wang; Meng Cong; Mi Shen; Qianru He; Fei Ding; Haiyan Shi
Journal:  Ann Transl Med       Date:  2020-12

3.  Extracellular vesicle-encapsulated microRNA-424 exerts inhibitory function in ovarian cancer by targeting MYB.

Authors:  Ping Li; Hongyan Xin; Lili Lu
Journal:  J Transl Med       Date:  2021-01-06       Impact factor: 5.531

Review 4.  Mesenchymal Stem Cell-Derived Extracellular Vesicle: A Promising Alternative Therapy for Osteoporosis.

Authors:  Cheng-Hsiu Lu; Yi-An Chen; Chien-Chih Ke; Ren-Shyan Liu
Journal:  Int J Mol Sci       Date:  2021-11-25       Impact factor: 5.923

Review 5.  Stem Cell-Derived Exosome as Potential Therapeutics for Microbial Diseases.

Authors:  Somayeh Keshtkar; Maryam Kaviani; Saeede Soleimanian; Negar Azarpira; Zahra Asvar; Sara Pakbaz
Journal:  Front Microbiol       Date:  2022-02-14       Impact factor: 5.640

Review 6.  Scalable Production of Extracellular Vesicles and Its Therapeutic Values: A Review.

Authors:  Chiew Yong Ng; Li Ting Kee; Maimonah Eissa Al-Masawa; Qian Hui Lee; Thayaalini Subramaniam; David Kok; Min Hwei Ng; Jia Xian Law
Journal:  Int J Mol Sci       Date:  2022-07-20       Impact factor: 6.208

7.  microRNA-375 released from extracellular vesicles of bone marrow mesenchymal stem cells exerts anti-oncogenic effects against cervical cancer.

Authors:  Feng Ding; Jinhua Liu; Xiaofei Zhang
Journal:  Stem Cell Res Ther       Date:  2020-10-27       Impact factor: 6.832

Review 8.  News about Therapies of Alzheimer's Disease: Extracellular Vesicles from Stem Cells Exhibit Advantages Compared to Other Treatments.

Authors:  Jacopo Meldolesi
Journal:  Biomedicines       Date:  2022-01-05
  8 in total

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