Rhailana Medeiros Fontes1, Victor Marinho1,2, Valécia Carvalho1,2, Kaline Rocha1,2, Francisco Magalhães1,2, Iris Moura1,3, Pedro Ribeiro4, Bruna Velasques4, Mauricio Cagy4, Daya S Gupta5, Victor Hugo Bastos2,3,6, Ariel Soares Teles1,3,7, Silmar Teixeira1,2,3. 1. Neuro-Innovation Technology & Brain Mapping Laboratory, Federal University of Piauí, Parnaíba, Brazil. 2. The Northeast Biotechnology Network, Federal University of Piauí, Teresina, Brazil. 3. Masters Programs in Biotechnology, Federal University of Piauí, Parnaíba, Brazil. 4. Brain Mapping and Sensory Motor Integration Laboratory, Institute of Psychiatry, Federal University of Rio De Janeiro, Rio De Janeiro, Brazil. 5. Department of Biology, Camden County College, Blackwood, NJ, USA. 6. Brain Mapping and Functionality Laboratory, Federal University of Piauí, Parnaíba, Brazil. 7. Federal Institute of Maranhão, Maranhão, Brazil.
Abstract
AIM: This study investigated whether time-estimation task exposure influences the severity of Attention Deficit Hyperactivity Disorder (ADHD), as well as theta band activity in the dorsolateral prefrontal cortex and ventrolateral prefrontal cortex. MATERIAL AND METHODS:Twenty-two patients with ADHD participated in a crossover experiment with a visual time-estimation task under control conditions (without exposure to time estimation tasks) and experimental (thirty days exposure to time-estimation tasks) in association with electroencephalographic analysis of theta band. RESULTS: ADHD patients with thirty days of time-estimation task exposure presented a worse performance of the time-estimation task, as revealed by the measurements of the absolute error and relative error (p ≤ 0.05). However, our findings show the improvement of self-reported symptoms of attention, impulsivity, and emotional control in patients after the time-estimation task exposure (p = 0.0001). Moreover, the theta band oscillations in the right dorsolateral prefrontal cortex and in the ventrolateral prefrontal increased with thirty days of time-estimation task exposure (p ≤ 0.05). CONCLUSION: We propose that the decrease in EEG theta power may indicate an efficient accumulation of temporal pulses, which could be responsible for the improvement in the patient cognitive aspects as demonstrated by the current study. Time-estimation task improves ADHD cognitive symptoms, with a substantial increase in cortical areas activity related to attention and memory, suggesting its use as a tool for cognitive timing function management and non-invasive therapeutic aid in ADHD.
RCT Entities:
AIM: This study investigated whether time-estimation task exposure influences the severity of Attention Deficit Hyperactivity Disorder (ADHD), as well as theta band activity in the dorsolateral prefrontal cortex and ventrolateral prefrontal cortex. MATERIAL AND METHODS: Twenty-two patients with ADHD participated in a crossover experiment with a visual time-estimation task under control conditions (without exposure to time estimation tasks) and experimental (thirty days exposure to time-estimation tasks) in association with electroencephalographic analysis of theta band. RESULTS:ADHDpatients with thirty days of time-estimation task exposure presented a worse performance of the time-estimation task, as revealed by the measurements of the absolute error and relative error (p ≤ 0.05). However, our findings show the improvement of self-reported symptoms of attention, impulsivity, and emotional control in patients after the time-estimation task exposure (p = 0.0001). Moreover, the theta band oscillations in the right dorsolateral prefrontal cortex and in the ventrolateral prefrontal increased with thirty days of time-estimation task exposure (p ≤ 0.05). CONCLUSION: We propose that the decrease in EEG theta power may indicate an efficient accumulation of temporal pulses, which could be responsible for the improvement in the patient cognitive aspects as demonstrated by the current study. Time-estimation task improves ADHD cognitive symptoms, with a substantial increase in cortical areas activity related to attention and memory, suggesting its use as a tool for cognitive timing function management and non-invasive therapeutic aid in ADHD.
Entities:
Keywords:
electroencephalography; Attention deficit hyperactivity disorder; theta band; time perception
Authors: Radek Ptáček; Martina Vňuková; Filip Děchtěrenko; Simon Weissenberger; Eva Kitzlerová; Hana Ptáčková; Martin Anders Journal: Med Sci Monit Date: 2022-07-16