Literature DB >> 31927622

FG 7142: is this validated tool to study anxiety now forgotten?

R Horowski1.   

Abstract

We describe the first human experience with FG 7142, a drug which in a phase I study has caused severe anxiety attacks and which therefore could be a validated tool for further experimental studies of anxiety.

Entities:  

Keywords:  Anxiety attacks; FG 7142

Year:  2020        PMID： 31927622     DOI： 10.1007/s00702-019-02136-3

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  14 in total

1.  Anxiogenic, not psychotogenic, properties of the partial inverse benzodiazepine receptor agonist FG 7142 in man.

Authors:  R Horowski; R Dorrow
Journal:  Psychopharmacology (Berl)       Date:  2002-07       Impact factor: 4.530

2.  Severe anxiety induced by FG 7142, a beta-carboline ligand for benzodiazepine receptors.

Authors:  R Dorow; R Horowski; G Paschelke; M Amin
Journal:  Lancet       Date:  1983-07-09       Impact factor: 79.321

Review 3.  Anxiogenic properties of beta-CCE and FG 7142: a review of promises and pitfalls.

Authors:  M H Thiébot; P Soubrié; D Sanger
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530

4.  Anxiolytic and anxiogenic beta-carbolines: tools for the study of anxiety mechanisms.

Authors:  D N Stephens; W Kehr; T Duka
Journal:  Adv Biochem Psychopharmacol       Date:  1986

5.  Effects of the beta-carboline, FG 7142, in the social interaction test of anxiety and the holeboard: correlations between behaviour and plasma concentrations.

Authors:  S E File; S Pellow; C Braestrup
Journal:  Pharmacol Biochem Behav       Date:  1985-06       Impact factor: 3.533

6.  Neuropharmacological antagonism of the beta-carboline-induced "anxiety" response in rhesus monkeys.

Authors:  J N Crawley; P T Ninan; D Pickar; G P Chrousos; M Linnoila; P Skolnick; S M Paul
Journal:  J Neurosci       Date:  1985-02       Impact factor: 6.167

7.  Kindling to the benzodiazepine receptor inverse agonist, FG 7142: evidence for involvement of NMDA, but not non-NMDA, glutamatergic receptors.

Authors:  D N Stephens; L Turski
Journal:  Neuropharmacology       Date:  1993-10       Impact factor: 5.250

8.  A PET study following treatment with a pharmacological stressor, FG7142, in conscious rhesus monkeys.

Authors:  Hiroyuki Takamatsu; Akihiro Noda; Akeo Kurumaji; Yoshihiro Murakami; Mitsuyoshi Tatsumi; Rikiya Ichise; Shintaro Nishimura
Journal:  Brain Res       Date:  2003-08-08       Impact factor: 3.252

9.  Interaction of convulsive ligands with benzodiazepine receptors.

Authors:  C Braestrup; R Schmiechen; G Neef; M Nielsen; E N Petersen
Journal:  Science       Date:  1982-06-11       Impact factor: 47.728

10.  Amnestic effects of lormetazepam and their reversal by the benzodiazepine antagonist Ro 15-1788.

Authors:  R Dorow; D Berenberg; T Duka; N Sauerbrey
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530
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  1 in total

Review 1.  Dependence liability of lormetazepam: are all benzodiazepines equal? The case of the new i.v. lormetazepam for anesthetic procedures.

Authors:  Reinhard Horowski
Journal:  J Neural Transm (Vienna)       Date:  2020-05-28       Impact factor: 3.575
  1 in total

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