Literature DB >> 31927579

Success of malaria chemoprophylaxis for outbound civil and military travellers in prevention of reintroduction of malaria in Sri Lanka.

Sumadhya D Fernando1, Dewanee Ranaweera2, Methnie S Weerasena2, Rahuman Booso3, Thamara Wickramasekara4, Chirath P Madurapperuma1, Manjula Danansuriya2, Chaturaka Rodrigo5, Hemantha Herath2.   

Abstract

BACKGROUND: Sri Lanka was certified as malaria-free in September 2016. However, the continuous presence of the malaria vector poses serious risks of reintroduction of the disease. Chemoprophylaxis and advice on malaria preventive behaviour for international travellers is a key strategy adopted to reduce the risk of imported malaria.
METHODS: We conducted an efficiency study of malaria chemoprophylaxis for civilian and military travellers who requested travel advice from the Anti Malaria Campaign (AMC) prior to departure. The AMC is the only agency that can issue malaria chemoprophylaxis to travellers and hence this sample is representative of all such individuals seeking travel advice in Sri Lanka.
RESULTS: A total of 544 (400 civilians and 144 military) travellers were interviewed prior to departure and after return. The majority travelled to African destinations (516/544 [94.8%]) and were prescribed mefloquine (517/544 [95%]). Chemoprophylaxis was well tolerated and discontinuation due to adverse events was minimal. Regular chemoprophylaxis was reported by 505 (92.8%) participants while overseas. The protective efficacy of chemoprophylaxis was 100% among those who complied with the full course.
CONCLUSIONS: The compliance with chemoprophylaxis and its protective efficacy were satisfactory in this study. It is an effective tool in preventing imported malaria to post-elimination Sri Lanka.
© The Author(s) 2019. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene.

Entities:  

Keywords:  chemoprophylaxis; adverse effects; imported malaria; malaria; mefloquine; reintroduction

Mesh:

Substances:

Year:  2020        PMID: 31927579      PMCID: PMC7322204          DOI: 10.1093/inthealth/ihz094

Source DB:  PubMed          Journal:  Int Health        ISSN: 1876-3405            Impact factor:   2.473


  24 in total

1.  Mefloquine and doxycycline malaria prophylaxis in Australian soldiers in East Timor.

Authors:  Scott J Kitchener; Peter E Nasveld; Robin M Gregory; Michael D Edstein
Journal:  Med J Aust       Date:  2005-02-21       Impact factor: 7.738

2.  WHO Expert Committee on Malaria. Twelfth report.

Authors: 
Journal:  World Health Organ Tech Rep Ser       Date:  1966

3.  The adverse effects of mefloquine in deployed military personnel.

Authors:  S Adshead
Journal:  J R Nav Med Serv       Date:  2014

4.  Rolling back malaria: how well is Europe doing?

Authors:  Stephen Toovey; Andrew Jamieson
Journal:  Travel Med Infect Dis       Date:  2003-08       Impact factor: 6.211

5.  Assessment of adherence to atovaquone-proguanil prophylaxis in travelers.

Authors:  John C DePetrillo; Carol Singer; Isabella A Bergagnini; Patricia Kolakowski; Barbara Edwards; Miriam A Smith
Journal:  J Travel Med       Date:  2010 Jul-Aug       Impact factor: 8.490

6.  From malaria control to eradication: The WHO perspective.

Authors:  Kamini Mendis; Aafje Rietveld; Marian Warsame; Andrea Bosman; Brian Greenwood; Walther H Wernsdorfer
Journal:  Trop Med Int Health       Date:  2009-05-26       Impact factor: 2.622

7.  The risk of severe depression, psychosis or panic attacks with prophylactic antimalarials.

Authors:  Christoph R Meier; Karen Wilcock; Susan S Jick
Journal:  Drug Saf       Date:  2004       Impact factor: 5.606

8.  Risk factors for malaria in UK travellers.

Authors:  David A Moore; Alison D Grant; Margaret Armstrong; Richard Stümpfle; Ron H Behrens
Journal:  Trans R Soc Trop Med Hyg       Date:  2004-01       Impact factor: 2.184

Review 9.  Safety evaluation of the drugs available to prevent malaria.

Authors:  Ashley M Croft; Dominic P Whitehouse; Gordon C Cook; M Dominic Beer
Journal:  Expert Opin Drug Saf       Date:  2002-05       Impact factor: 4.250

10.  Should chemoprophylaxis be a main strategy for preventing re-introduction of malaria in highly receptive areas? Sri Lanka a case in point.

Authors:  A Rajitha Wickremasinghe; Renu Wickremasinghe; Hemantha D B Herath; S Deepika Fernando
Journal:  Malar J       Date:  2017-03-04       Impact factor: 2.979

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  1 in total

Review 1.  Compliance with Primary Malaria Chemoprophylaxis: Is Weekly Prophylaxis Better Than Daily Prophylaxis?

Authors:  Chaturaka Rodrigo; Senaka Rajapakse; Sumadhya Deepika Fernando
Journal:  Patient Prefer Adherence       Date:  2020-11-09       Impact factor: 2.711

  1 in total

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