Zocko Ange Désiré Pockpa1,2, Xavier Struillou3, Dramane Kone4, Gnaba Samson Mobio4, Assem Soueidan2,3, Zahi Badran3. 1. Dental College, University of Nantes, France. 2. Clinic Unit of Investigation Odontologie, Dental College, University of Nantes, France. 3. Centre Hospitalier Universitaire de Nantes, France. 4. Department of Periodontology, Dental College, Felix Houphouet Boigny University, Abidjan, Cote d'Ivoire.
Abstract
BACKGROUND: Age-related macular degeneration (AMD) induces irreversible loss of vision in older people. The exact physiopathology remains unclear, but numerous studies highlight the role of inflammation and multiple risk factors. Recent data show an altered periodontal condition subject to AMD. Periodontal diseases lead to the destruction of tooth-supporting tissues, mainly caused by the periodontal infection inducing a chronic inflammation. Periodontal diseases are known to be associated with several extraoral diseases such as diabetes, polyarthritis (rheumatoid arthritis), cardiovascular disease, and preeclampsia. OBJECTIVES: To assess emerging evidence suggesting an association between periodontitis and AMD. METHODS: To support this review, we performed a literature search using PubMed, Cochrane, and Google Scholar databases, completed by manual searches in periodontology journals. We included only the original studies published before July 2017 reporting data on periodontal diseases and AMD. No restrictions were made on the language. RESULTS: Persons with AMD showed more periodontal diseases, fewer teeth, and more alveolar bone loss than those without AMD. Also, a significant association was observed between periodontal diseases and AMD, but only in the youngest individuals studied. CONCLUSION: According to the studies included in this review, periodontal disease may be a plausible risk factor for AMD and may have a potential role in the earlier stages of this eye disease. Further studies should be encouraged for better understanding of this potential new relationship.
BACKGROUND:Age-related macular degeneration (AMD) induces irreversible loss of vision in older people. The exact physiopathology remains unclear, but numerous studies highlight the role of inflammation and multiple risk factors. Recent data show an altered periodontal condition subject to AMD. Periodontal diseases lead to the destruction of tooth-supporting tissues, mainly caused by the periodontal infection inducing a chronic inflammation. Periodontal diseases are known to be associated with several extraoral diseases such as diabetes, polyarthritis (rheumatoid arthritis), cardiovascular disease, and preeclampsia. OBJECTIVES: To assess emerging evidence suggesting an association between periodontitis and AMD. METHODS: To support this review, we performed a literature search using PubMed, Cochrane, and Google Scholar databases, completed by manual searches in periodontology journals. We included only the original studies published before July 2017 reporting data on periodontal diseases and AMD. No restrictions were made on the language. RESULTS:Persons with AMD showed more periodontal diseases, fewer teeth, and more alveolar bone loss than those without AMD. Also, a significant association was observed between periodontal diseases and AMD, but only in the youngest individuals studied. CONCLUSION: According to the studies included in this review, periodontal disease may be a plausible risk factor for AMD and may have a potential role in the earlier stages of this eye disease. Further studies should be encouraged for better understanding of this potential new relationship.
Authors: Paul I Eke; Liang Wei; Wenche S Borgnakke; Gina Thornton-Evans; Xingyou Zhang; Hua Lu; Lisa C McGuire; Robert J Genco Journal: Periodontol 2000 Date: 2016-10 Impact factor: 7.589
Authors: Vinod P Mitta; William G Christen; Robert J Glynn; Richard D Semba; Paul M Ridker; Eric B Rimm; Susan E Hankinson; Debra A Schaumberg Journal: JAMA Ophthalmol Date: 2013-04 Impact factor: 7.389
Authors: A C Bird; N M Bressler; S B Bressler; I H Chisholm; G Coscas; M D Davis; P T de Jong; C C Klaver; B E Klein; R Klein Journal: Surv Ophthalmol Date: 1995 Mar-Apr Impact factor: 6.048
Authors: Anny J Camelo-Castillo; Alex Mira; Alex Pico; Luigi Nibali; Brian Henderson; Nikolaos Donos; Inmaculada Tomás Journal: Front Microbiol Date: 2015-02-24 Impact factor: 5.640
Authors: Anu Kauppinen; Jussi J Paterno; Janusz Blasiak; Antero Salminen; Kai Kaarniranta Journal: Cell Mol Life Sci Date: 2016-02-06 Impact factor: 9.261
Authors: Ryan T Demmer; Birte Holtfreter; Moïse Desvarieux; David R Jacobs; Wolfgang Kerner; Matthias Nauck; Henry Völzke; Thomas Kocher Journal: Diabetes Care Date: 2012-08-01 Impact factor: 19.112