Literature DB >> 31925673

Various Manifestations of 5-Fluorouracil Cardiotoxicity: A Multicenter Case Series and Review of Literature.

John D Allison1, Toug Tanavin2, Yang Yang2, Gilad Birnbaum2, Umair Khalid2.   

Abstract

5-Fluorouracil is a key element to the treatment of colon cancer. But it is also one of the most cardiotoxic chemotherapies, and the management of those that experience cardiotoxicity can be challenging. We present three cases of 5-FU cardiac toxicity that manifested as myocardial infarction, cardiogenic shock, and ventricular fibrillation. Additionally, we discuss the current literature regarding 5-fluorouracil cardiotoxicity mechanisms as well as management.

Entities:  

Keywords:  5-Fluorouracil; Acute myocardial infarction; Arrhythmia; Cardiogenic shock; Cardiotoxicity; Chemotherapy; Colon cancer; Pharmacotherapy; Ventricular fibrillation

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Substances：

Year:  2020        PMID： 31925673     DOI： 10.1007/s12012-020-09562-w

Source DB:  PubMed          Journal:  Cardiovasc Toxicol        ISSN： 1530-7905            Impact factor:   3.231


  3 in total

Review 1.  5-FU Cardiotoxicity: Vasospasm, Myocarditis, and Sudden Death.

Authors:  Luis Alberto More; Sarah Lane; Aarti Asnani
Journal:  Curr Cardiol Rep       Date:  2021-02-03       Impact factor: 2.931

2.  Myricetin (3,3',4',5,5',7-Hexahydroxyflavone) Prevents 5-Fluorouracil-Induced Cardiotoxicity.

Authors:  Azher Arafah; Muneeb U Rehman; Ajaz Ahmad; Khalid M AlKharfy; Saeed Alqahtani; Basit L Jan; Nada M Almatroudi
Journal:  ACS Omega       Date:  2022-01-25

3.  Xanthohumol, a Prenylated Flavonoid from Hops, Induces DNA Damages in Colorectal Cancer Cells and Sensitizes SW480 Cells to the SN38 Chemotherapeutic Agent.

Authors:  Alessandra Scagliarini; Aline Mathey; Virginie Aires; Dominique Delmas
Journal:  Cells       Date:  2020-04-10       Impact factor: 6.600
  3 in total

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