Dandan Linghu1,2,3,4, Hui Xu1,2,3,4, Zhiqiao Liang1,2,3,4, Tingting Gao1,2,3,4, Zhaojun Lin1, Xiaoxin Li1,2,3,4, Lvzhen Huang1,2,3,4, Mingwei Zhao5,6,7,8. 1. Department of Ophthalmology, Peking University People's Hospital, Xizhimen South Street No. 11, Beijing, 100044, China. 2. Eye Diseases and Optometry Institute, Beijing, China. 3. Beijing Key Laboratory of Diagnosis and Therapy of Retina and Choroid Diseases, Beijing, China. 4. College of Optometry, Peking University Health Science Center, Beijing, China. 5. Department of Ophthalmology, Peking University People's Hospital, Xizhimen South Street No. 11, Beijing, 100044, China. rmykzmw@sina.com. 6. Eye Diseases and Optometry Institute, Beijing, China. rmykzmw@sina.com. 7. Beijing Key Laboratory of Diagnosis and Therapy of Retina and Choroid Diseases, Beijing, China. rmykzmw@sina.com. 8. College of Optometry, Peking University Health Science Center, Beijing, China. rmykzmw@sina.com.
Abstract
PURPOSE: To evaluate the association between single nucleotide polymorphisms (SNPs) in the complement factor H (CFH) gene and response to PDT in patients with CSC. METHODS: 103 eyes from 93 patients with CSC were enrolled from Department of Ophthalmology of the People's Hospital Peking University. Genotyping for selected SNPs in the CFH gene was performed, and multivariate linear analysis was used to identify factors influencing PDT treatment outcomes. Genetics associations between SNPs in the CFH gene and response to PDT in patients with CSC were analyzed. RESULTS: None of the seven SNPs examined in this study (rs800292, rs1061170, rs3753394, rs3753396, rs2284664, rs1329428, and rs1065489) showed significant associations with 1-month outcomes after PDT in patients with CSC (P > 0.05). Baseline BCVA changed at 1 month after PDT (P < 0.001), and baseline retinal thickness was associated with changes in retinal thickness at 1 month after PDT (P < 0.001). Age was significantly associated with resolution of SRF at 1 month after PDT (P = 0.004). CONCLUSIONS: There were no significant associations between SNPs in the CFH gene and 1-month outcomes after PDT in patients with CSC. However, baseline BCVA, baseline retinal thickness, and age were significantly associated with response to PDT in patients with CSC. Larger studies with more power are necessary to further determine whether an association exists between SNPs in the CFH gene and PDT in patients with CSC.
PURPOSE: To evaluate the association between single nucleotide polymorphisms (SNPs) in the complement factor H (CFH) gene and response to PDT in patients with CSC. METHODS: 103 eyes from 93 patients with CSC were enrolled from Department of Ophthalmology of the People's Hospital Peking University. Genotyping for selected SNPs in the CFH gene was performed, and multivariate linear analysis was used to identify factors influencing PDT treatment outcomes. Genetics associations between SNPs in the CFH gene and response to PDT in patients with CSC were analyzed. RESULTS: None of the seven SNPs examined in this study (rs800292, rs1061170, rs3753394, rs3753396, rs2284664, rs1329428, and rs1065489) showed significant associations with 1-month outcomes after PDT in patients with CSC (P > 0.05). Baseline BCVA changed at 1 month after PDT (P < 0.001), and baseline retinal thickness was associated with changes in retinal thickness at 1 month after PDT (P < 0.001). Age was significantly associated with resolution of SRF at 1 month after PDT (P = 0.004). CONCLUSIONS: There were no significant associations between SNPs in the CFH gene and 1-month outcomes after PDT in patients with CSC. However, baseline BCVA, baseline retinal thickness, and age were significantly associated with response to PDT in patients with CSC. Larger studies with more power are necessary to further determine whether an association exists between SNPs in the CFH gene and PDT in patients with CSC.
Entities:
Keywords:
Central serous chorioretinopathy; Complement factor H; Single nucleotide polymorphisms; Verteporfin photodynamic therapy
Authors: Eiko K de Jong; Myrte B Breukink; Rosa L Schellevis; Bjorn Bakker; Jacqueline K Mohr; Sascha Fauser; Jan E E Keunen; Carel B Hoyng; Anneke I den Hollander; Camiel J F Boon Journal: Ophthalmology Date: 2014-11-06 Impact factor: 12.079