| Literature DB >> 31924140 |
Marília C A Machado1,2,3,4, Natalia M Ocarino1,2,3,4, Rogéria Serakides1,2,3,4, Ludmila R Moroz1,2,3,4, Angelo Sementilli1,2,3,4, Karine A Damasceno1,2,3,4, Claudia H Cruz1,2,3,4, Alessandra Estrela-Lima1,2,3,4.
Abstract
Triple-negative tumors are characterized immunohistochemically by the absence of positivity to sex hormone receptors and to human epidermal growth factor receptor 2. Additionally, they are differentiated into basal-like and non-basal (or null) subtypes, based on the presence of basal cytokeratin expression (CK5/6, 14, and17). Triple-negative subtypes are yet to be characterized in male dogs, to our knowledge. We report herein the clinical and pathologic findings and molecular characterization of carcinoma in the mammary glands of 2 male dogs. Case 1 was diagnosed as a grade II tubulopapillary carcinoma; case 2 was diagnosed as a grade II carcinoma in a mixed tumor. The tumors were characterized phenotypically as triple-negative basal and triple-negative non-basal, respectively.Entities:
Keywords: cancer; immunohistochemistry; male dogs; mammary carcinoma; molecular phenotype; prognosis
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Year: 2020 PMID： 31924140 PMCID： PMC7003223 DOI： 10.1177/1040638719898686
Source DB: PubMed Journal: J Vet Diagn Invest ISSN： 1040-6387 Impact factor: 1.279