pH and thermal dual-responsive poly(NIPAM-co-GMA)-coated magnetic nanoparticles via surface-initiated RAFT polymerization for controlled drug delivery.

Herein, a novel type of multifunctional magnetic nanoparticles with dual thermal and pH-responsive behavior was fabricated as the carrier for delivery of doxorubicin (DOX). Fe3O4@SiO2 magnetic nanoparticles, were grafted with polymer brushes consisting of poly (NIPAM-co-GMA) (PNG) chains via surface initiated reversible addition-fragmentation chain transfer (SI-RAFT) polymerization. The polymer brushes were then modified with hydrazine groups as DOX binding sites. The prepared multifunctional magnetic nanoparticles were characterized by FT-IR, 1H NMR, XPS, TGA, DLS, VSM, GPC, TEM, and XRD analysis. The in vitro drug release of the multifunctional magnetic nanoparticles was examined at 37 °C (above LCST) and 25 °C (below LCST) in different pH media and exhibited excellent pH- and thermo-sensitive behavior. The results show that the Fe3O4@SiO2@PNG-Hy fabricated via SI-RAFT polymerization is a viable candidate material for tumor treatment studies.