So Young Kim1, Hye-Rim Kim2, Chanyang Min3,4, Dong Jun Oh5, Bumjung Park6, Hyo Geun Choi7,8. 1. Department of Otorhinolaryngology-Head & Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Korea. 2. Department of Pediatrics, CHA Bundang Medical Center, CHA University, Seongnam, Korea. 3. Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang, Korea. 4. Graduate School of Public Health, Seoul National University, Seoul, Korea. 5. Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. 6. Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University College of Medicine, Anyang, Korea. 7. Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang, Korea. pupen@naver.com. 8. Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University College of Medicine, Anyang, Korea. pupen@naver.com.
Abstract
BACKGROUND: The causal relationship between asthma and gastroesophageal reflux disease (GERD) is unknown in children. METHODS: The Korean Health Insurance Review and Assessment Service-National Sample Cohort 2002-2013 was used. The population age <15 years was selected. In study I, 86,096 asthmatic children were 1:1 matched with 86,096 control I participants. In study II, 532 GERD children were 1:2 matched with 1064 control II participants. The stratified Cox proportional hazard ratios for GERD in patients with asthma (study I) and asthma in patients with GERD (study II) were analyzed. RESULTS: In total, 0.7% (583/86,096) of the asthma group and 0.5% (430/86,096) of the control I group had GERD (P < 0.001). The asthma group demonstrated a 1.36 times higher HR for GERD than the control I group (95% CI = 1.20-1.54, P < 0.001). Subgroup analyses according to age and sex showed consistent results. In total, 15.0% (80/532) of the GERD group and 10.0% (106/1,064) of the control II group had asthma (P < 0.001). The GERD group showed a 1.62-fold higher HR for asthma than the control II group (95% CI = 1.21-2.18, P < 0.001). CONCLUSION: GERD and asthma demonstrated a bidirectional relationship in children.
BACKGROUND: The causal relationship between asthma and gastroesophageal reflux disease (GERD) is unknown in children. METHODS: The Korean Health Insurance Review and Assessment Service-National Sample Cohort 2002-2013 was used. The population age <15 years was selected. In study I, 86,096 asthmatic children were 1:1 matched with 86,096 control I participants. In study II, 532 GERDchildren were 1:2 matched with 1064 control II participants. The stratified Cox proportional hazard ratios for GERD in patients with asthma (study I) and asthma in patients with GERD (study II) were analyzed. RESULTS: In total, 0.7% (583/86,096) of the asthma group and 0.5% (430/86,096) of the control I group had GERD (P < 0.001). The asthma group demonstrated a 1.36 times higher HR for GERD than the control I group (95% CI = 1.20-1.54, P < 0.001). Subgroup analyses according to age and sex showed consistent results. In total, 15.0% (80/532) of the GERD group and 10.0% (106/1,064) of the control II group had asthma (P < 0.001). The GERD group showed a 1.62-fold higher HR for asthma than the control II group (95% CI = 1.21-2.18, P < 0.001). CONCLUSION:GERD and asthma demonstrated a bidirectional relationship in children.