Literature DB >> 31923746

Tissue-specific disruption of the growth hormone receptor (GHR) in mice: An update.

Silvana Duran-Ortiz1, Vanessa Noboa2, John J Kopchick3.   

Abstract

The Growth hormone receptor (GHR) is expressed in many cells/tissues in the body. To investigate the specific metabolic effects of GH action in distinct tissues, several tissue-specific GHR gene disrupted or knockout (KO) mouse lines have been generated. Previously, we have described the effects of GHRKO in several known insulin sensitive tissues, namely liver, muscle and adipose tissue. In this review, we further explore and summarize the main findings of recently published GHRKO results in liver, adipocytes, intestine, bone, brain and heart.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Adipose tissue; Bone; Brain; Growth hormone receptor; Heart; IGF-I; Intestine; Liver; Macrophages; Tissue-specific

Mesh：

Substances：

Year:  2019        PMID： 31923746     DOI： 10.1016/j.ghir.2019.12.004

Source DB:  PubMed          Journal:  Growth Horm IGF Res        ISSN： 1096-6374            Impact factor:   2.372


  4 in total

1.  CSF1R-dependent macrophages control postnatal somatic growth and organ maturation.

Authors:  Sahar Keshvari; Melanie Caruso; Ngari Teakle; Lena Batoon; Anuj Sehgal; Omkar L Patkar; Michelle Ferrari-Cestari; Cameron E Snell; Chen Chen; Alex Stevenson; Felicity M Davis; Stephen J Bush; Clare Pridans; Kim M Summers; Allison R Pettit; Katharine M Irvine; David A Hume
Journal:  PLoS Genet       Date:  2021-06-03       Impact factor: 5.917

2.  Sex-specific phenotypic effects and evolutionary history of an ancient polymorphic deletion of the human growth hormone receptor.

Authors:  Marie Saitou; Skyler Resendez; Apoorva J Pradhan; Fuguo Wu; Natasha C Lie; Nancy J Hall; Qihui Zhu; Laura Reinholdt; Yoko Satta; Leo Speidel; Shigeki Nakagome; Neil A Hanchard; Gary Churchill; Charles Lee; G Ekin Atilla-Gokcumen; Xiuqian Mu; Omer Gokcumen
Journal:  Sci Adv       Date:  2021-09-24       Impact factor: 14.136

3.  Systemic Deficiency of GHR in Pigs leads to Hepatic Steatosis via Negative Regulation of AHR Signaling.

Authors:  Qi Han; Huiling Chen; Likai Wang; Yang An; Xiaoxiang Hu; Yaofeng Zhao; Hao Zhang; Ran Zhang
Journal:  Int J Biol Sci       Date:  2021-10-03       Impact factor: 6.580

4.  Identifying Protein-metabolite Networks Associated with COPD Phenotypes.

Authors:  Emily Mastej; Lucas Gillenwater; Yonghua Zhuang; Katherine A Pratte; Russell P Bowler; Katerina Kechris
Journal:  Metabolites       Date:  2020-03-25
  4 in total

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