Wei-Ju Lee1, Li-Ning Peng2, Ching-Hui Loh3, Liang-Kung Chen4. 1. Aging and Health Research Center, National Yang Ming University School of Medicine, 155, Sec. 2, Linong St., Taipei 11221, Taiwan; Department of Geriatric Medicine, National Yang Ming University School of Medicine, 155, Sec. 2, Linong St., Taipei 11221, Taiwan; Department of Family Medicine, Taipei Veterans General Hospital, Yuanshan Branch, 386 Rongguang Rd., Yuanshan Township, Yilan County 264, Taiwan. 2. Aging and Health Research Center, National Yang Ming University School of Medicine, 155, Sec. 2, Linong St., Taipei 11221, Taiwan; Department of Geriatric Medicine, National Yang Ming University School of Medicine, 155, Sec. 2, Linong St., Taipei 11221, Taiwan; Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, 201, Sec. 2, Shih-Pai Rd., Taipei 11217, Taiwan. 3. Aging and Health Research Center, National Yang Ming University School of Medicine, 155, Sec. 2, Linong St., Taipei 11221, Taiwan; Department of Geriatric Medicine, National Yang Ming University School of Medicine, 155, Sec. 2, Linong St., Taipei 11221, Taiwan; Center of Health and Aging, Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation, 707, Sec. 3, Chung-Yang Rd., Hualien County 970, Taiwan. 4. Aging and Health Research Center, National Yang Ming University School of Medicine, 155, Sec. 2, Linong St., Taipei 11221, Taiwan; Department of Geriatric Medicine, National Yang Ming University School of Medicine, 155, Sec. 2, Linong St., Taipei 11221, Taiwan; Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, 201, Sec. 2, Shih-Pai Rd., Taipei 11217, Taiwan. Electronic address: lkchen2@vghtpe.gov.tw.
Abstract
BACKGROUND: Both serum homocysteine and high sensitivity C - reactive protein (hsCRP) are inflammatory markers related to vascular aging. Little was known about relationship between hsCRP and homocysteine and sarcopenia. The study aimed to explore the association between these two biomarkers and sarcopenia and its components. METHODS: Data of 1582 participants excerpted from first wave of I-Lan Longitudinal Aging Study. Sarcopenia was defined according to criteria of the Asian Working Group of Sarcopenia. Logistic regression was employed to examine the aforementioned associations. RESULTS: High levels of homocysteine (OR 1.9, 95% CI 1.0-3.6) and hsCRP (OR 3.9, 95% CI 2.2-6.9) were independently associated with sarcopenia. Both biomarkers were significantly associated with weakness (OR 2.9, 95%CI 2.1-4.0 for high level of homocysteine; OR 1.6, 95% CI 1.2-2.0 for high level of hsCRP) and slowness (OR 2.0, 95%CI 1.3-3.0 for high level of homocysteine; OR1.5, 95% CI1.1-2.2 for high level of hsCRP). Stronger associations between high levels of homocysteine and sarcopenia were noted in the women. CONCLUSION: The study confirmed positive association between homocysteine, hsCRP and sarcopenia and further highlighted potential roles of both biomarkers in sarcopenia development. Intervention studies are needed to evaluate potential therapeutic benefits of lowering homocysteine and hsCRP in managing sarcopenia.
BACKGROUND: Both serum homocysteine and high sensitivity C - reactive protein (hsCRP) are inflammatory markers related to vascular aging. Little was known about relationship between hsCRP and homocysteine and sarcopenia. The study aimed to explore the association between these two biomarkers and sarcopenia and its components. METHODS: Data of 1582 participants excerpted from first wave of I-Lan Longitudinal Aging Study. Sarcopenia was defined according to criteria of the Asian Working Group of Sarcopenia. Logistic regression was employed to examine the aforementioned associations. RESULTS: High levels of homocysteine (OR 1.9, 95% CI 1.0-3.6) and hsCRP (OR 3.9, 95% CI 2.2-6.9) were independently associated with sarcopenia. Both biomarkers were significantly associated with weakness (OR 2.9, 95%CI 2.1-4.0 for high level of homocysteine; OR 1.6, 95% CI 1.2-2.0 for high level of hsCRP) and slowness (OR 2.0, 95%CI 1.3-3.0 for high level of homocysteine; OR1.5, 95% CI1.1-2.2 for high level of hsCRP). Stronger associations between high levels of homocysteine and sarcopenia were noted in the women. CONCLUSION: The study confirmed positive association between homocysteine, hsCRP and sarcopenia and further highlighted potential roles of both biomarkers in sarcopenia development. Intervention studies are needed to evaluate potential therapeutic benefits of lowering homocysteine and hsCRP in managing sarcopenia.
Authors: Kristina R Gopcevic; Eugenia Gkaliagkousi; János Nemcsik; Ömür Acet; M Rosa Bernal-Lopez; Rosa M Bruno; Rachel E Climie; Nikolaos Fountoulakis; Emil Fraenkel; Antonios Lazaridis; Petras Navickas; Keith D Rochfort; Agnė Šatrauskienė; Jūratė Zupkauskienė; Dimitrios Terentes-Printzios Journal: Front Physiol Date: 2021-12-14 Impact factor: 4.566