| Literature DB >> 31922153 |
Gang Xue1, Jiahui Chen, Lihong Liu, Danli Zhou, Yingying Zuo, Tiancheng Fu, Zhengying Pan.
Abstract
Tremendous advancements in proteolysis targeting chimera (PROTAC) technology have been made in recent years. However, whether a covalent inhibitor-based PROTAC can be developed remains controversial. Here, we successfully developed chimeric degraders based on covalent inhibitors to degrade BTK and BLK kinases, demonstrating that covalent inhibitor-based PROTACs are viable and useful tools.Entities:
Mesh：
Substances：
Year: 2020 PMID： 31922153 DOI： 10.1039/c9cc08238g
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222