Literature DB >> 3191999

ATP stimulates the uptake of S-dinitrophenylglutathione by rat liver plasma membrane vesicles.

K Kobayashi1, Y Sogame, K Hayashi, P Nicotera, S Orrenius.   

Abstract

Incubation of inverted plasma membrane vesicles from rat liver with micromolar concentrations of S-dinitrophenylglutathione (DNP-SG) in the presence of ATP resulted in the uptake of DNP-SG into the vesicles. ATP-dependent DNP-SG accumulation was half-maximal with 9 microM DNP-SG, while the Km for ATP was 320 microM. Glutathione disulfide (GSSG), but not reduced glutathione, inhibited the ATP-dependent accumulation of DNP-SG by the vesicles, suggesting that the same, ATP-dependent transport system is responsible for the extrusion of glutathione conjugates and GSSG from liver cells.

Entities:  

Mesh：

Substances：

Year:  1988        PMID： 3191999     DOI： 10.1016/0014-5793(88)80339-9

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  6 in total

1.  ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump.

Authors:  I Leier; G Jedlitschky; U Buchholz; M Center; S P Cole; R G Deeley; D Keppler
Journal:  Biochem J       Date:  1996-03-01       Impact factor: 3.857

2.  ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2.

Authors:  G Jedlitschky; I Leier; U Buchholz; J Hummel-Eisenbeiss; B Burchell; D Keppler
Journal:  Biochem J       Date:  1997-10-01       Impact factor: 3.857

3.  Magnesium Adenosine 5[prime]-Triphosphate-Energized Transport of Glutathione-S-Conjugates by Plant Vacuolar Membrane Vesicles.

Authors:  Z. S. Li; Y. Zhao; P. A. Rea
Journal:  Plant Physiol       Date:  1995-04       Impact factor: 8.340

4.  1-Chloro-2,4-Dinitrobenzene-Elicited Increase in Vacuolar Glutathione-S-Conjugate Transport Activity.

Authors:  Z. S. Li; R. G. Zhen; P. A. Rea
Journal:  Plant Physiol       Date:  1995-09       Impact factor: 8.340

5.  Adenosine triphosphate-dependent taurocholate transport in human liver plasma membranes.

Authors:  H Wolters; F Kuipers; M J Slooff; R J Vonk
Journal:  J Clin Invest       Date:  1992-12       Impact factor: 14.808

6.  Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes.

Authors:  R Mayer; J Kartenbeck; M Büchler; G Jedlitschky; I Leier; D Keppler
Journal:  J Cell Biol       Date:  1995-10       Impact factor: 10.539
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.