Vivek Krishna Nagarajan1, Jerrold M Ward2, Bing Yu1. 1. Department of Biomedical Engineering, Marquette University and Medical College of Wisconsin, Milwaukee, Wisconsin, 53045. 2. Global Vet Pathology, Montgomery Village, Maryland, 20886.
Abstract
BACKGROUND AND OBJECTIVES: Complete thermocoagulation of tumors is vital to minimize the risk of local tumor recurrence after a thermal ablation. Histological assessments are not real-time and require experienced pathologists to grade the thermal damage (histopathology) [Correction added on 21 January, 2020 after first online publication: After thermal damage in the preceding sentence, (histopathology) was added]. Real-time assessment of thermal tissue damage during an ablation is necessary to achieve optimal tumor ablation. In our previous studies, we found that continuous monitoring of the wavelength-averaged (435-630 nm) tissue absorption coefficient (µa ) and the reduced scattering coefficient ( μ s ' ) during heating of a porcine liver at 100°C follows a sigmoidal growth curve. Therefore, we concluded that increases in the tissue µa and μ s ' during thermocoagulation were correlated with true thermal damage. The goal of this study was to determine if increases in the tissue µa and μ s ' during thermocoagulation are correlated with true thermal damage. STUDY DESIGN/ MATERIALS AND METHODS: In this paper, continuously measured values of µa and μ s ' during heating of the porcine liver tissue were compared with the histology-assessed thermal damage scores at four different temperature points (37°C, 55°C, 65°C, and 75°C). RESULTS: The damage scores for the tissues in Group 3 (65°C) and Group 4 (75°C) were significantly different from each other and from the other groups. The damage scores were not significantly different between Group 1 (37°C) and Group 2 (55°C). CONCLUSION: The results indicate that relative changes in µa and μ s ' can be used to classify thermal damage (histopathology) scores with an overall accuracy of 72.5% up to 75°C. [Correction added on 21 January, 2020 after first online publication: After thermal damage in the preceding sentence, (histopathology) was added]. Lasers Surg. Med.
BACKGROUND AND OBJECTIVES: Complete thermocoagulation of tumors is vital to minimize the risk of local tumor recurrence after a thermal ablation. Histological assessments are not real-time and require experienced pathologists to grade the thermal damage (histopathology) [Correction added on 21 January, 2020 after first online publication: After thermal damage in the preceding sentence, (histopathology) was added]. Real-time assessment of thermal tissue damage during an ablation is necessary to achieve optimal tumor ablation. In our previous studies, we found that continuous monitoring of the wavelength-averaged (435-630 nm) tissue absorption coefficient (µa ) and the reduced scattering coefficient ( μ s ' ) during heating of a porcine liver at 100°C follows a sigmoidal growth curve. Therefore, we concluded that increases in the tissue µa and μ s ' during thermocoagulation were correlated with true thermal damage. The goal of this study was to determine if increases in the tissue µa and μ s ' during thermocoagulation are correlated with true thermal damage. STUDY DESIGN/ MATERIALS AND METHODS: In this paper, continuously measured values of µa and μ s ' during heating of the porcine liver tissue were compared with the histology-assessed thermal damage scores at four different temperature points (37°C, 55°C, 65°C, and 75°C). RESULTS: The damage scores for the tissues in Group 3 (65°C) and Group 4 (75°C) were significantly different from each other and from the other groups. The damage scores were not significantly different between Group 1 (37°C) and Group 2 (55°C). CONCLUSION: The results indicate that relative changes in µa and μ s ' can be used to classify thermal damage (histopathology) scores with an overall accuracy of 72.5% up to 75°C. [Correction added on 21 January, 2020 after first online publication: After thermal damage in the preceding sentence, (histopathology) was added]. Lasers Surg. Med.
Authors: Tyler W Iorizzo; Peter R Jermain; Elena Salomatina; Alona Muzikansky; Anna N Yaroslavsky Journal: Sci Rep Date: 2021-01-12 Impact factor: 4.379
Authors: Alla B Bucharskaya; Nikolai G Khlebtsov; Boris N Khlebtsov; Galina N Maslyakova; Nikita A Navolokin; Vadim D Genin; Elina A Genina; Valery V Tuchin Journal: Materials (Basel) Date: 2022-02-21 Impact factor: 3.623