Literature DB >> 3191946

A single cDNA encodes multiple Ly-6 antigenic specificities.

P E Korty1, D I Cohen, E M Shevach.   

Abstract

To determine the relationship between the structure and function of proteins coded for by the Ly-6 gene complex, we have transfected a cDNA for a Ly-6.2 specificity into COS-7 cells. A number of monoclonal antibodies which have been shown to be capable of inducing T cell activation and which have been previously considered to recognize distinct proteins all reacted with the same transfected gene product. The approach used in these studies should be useful to further elucidate the complexities of the Ly-6 alloantigen system.

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Year:  1988        PMID: 3191946     DOI: 10.1002/eji.1830181025

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN: 0014-2980            Impact factor:   5.532


  5 in total

1.  The isolation and sequence of the chromosomal gene and regulatory regions of Ly-6A.2.

Authors:  W L Stanford; E Bruyns; H R Snodgrass
Journal:  Immunogenetics       Date:  1992       Impact factor: 2.846

2.  A monoclonal antibody to Ly-6 gene product inhibits generation of functionally active T cells and recognizes single antigenic specificity whose expression is up-regulated in virus-transformed rat fibroblast.

Authors:  A Haque; M Chamekh; J Cornelis; A Capron; S Haque
Journal:  Immunology       Date:  1990-04       Impact factor: 7.397

3.  Analysis of three distinct Ly6-A-related cDNA sequences isolated from rat kidney.

Authors:  S Friedman; R G Palfree; S Sirlin; U Hämmerling
Journal:  Immunogenetics       Date:  1990       Impact factor: 2.846

4.  Expression of Ly-6A/E alloantigens in thymocyte and T-lymphocyte subsets: variability related to the Ly-6a and Ly-6b haplotypes.

Authors:  E K Codias; C Cray; R D Baler; R B Levy; T R Malek
Journal:  Immunogenetics       Date:  1989       Impact factor: 2.846

5.  Structure, expression, and genetic linkage of the mouse BCM1 (OX45 or Blast-1) antigen. Evidence for genetic duplication giving rise to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region on mouse chromosome 3.

Authors:  Y W Wong; A F Williams; S F Kingsmore; M F Seldin
Journal:  J Exp Med       Date:  1990-06-01       Impact factor: 14.307

  5 in total

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