Literature DB >> 3191944

Psychopharmacological effects of sertraline in normal, healthy volunteers.

I Hindmarch1, J Z Bhatti.   

Abstract

A double-blind, placebo controlled, cross-over study was carried out in 10 normal healthy volunteers to investigate the effects of sertraline 25 mg, 50 mg, 75 mg and 100 mg on aspects of cognitive functioning. Changes with respect to placebo in objective tests of psychomotor function (critical flicker fusion and choice reaction time) showed that sertraline had an alerting effect. The changes were not consistent with subjective reports of drowsiness.

Entities:  

Mesh：

Substances：

Year:  1988        PMID： 3191944     DOI： 10.1007/bf00609258

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  8 in total

1.  A repeated dose comparison of the side effects of five antihistamines on objective assessments of psychomotor performance, central nervous system arousal and subjective appraisals of sleep and early morning behaviour.

Authors:  I Hindmarch; A C Parrott
Journal:  Arzneimittelforschung       Date:  1978

2.  Repeated dose comparison of nomifensine, imipramine and placebo on subjective assessments of sleep and objective measures of psychomotor performance.

Authors:  I Hindmarch; A C Parrott
Journal:  Br J Clin Pharmacol       Date:  1977       Impact factor: 4.335

3.  EEG, blood level, and behavioral effects of the antidepressant mianserin (ORG GB-94).

Authors:  M Fink; P Irwin; M Gastpar; J J DeRidder
Journal:  Psychopharmacology (Berl)       Date:  1977-11-15       Impact factor: 4.530

4.  Pharmacodynamic comparison of the acute effects of nomifensine, amphetamine and placebo in healthy volunteers.

Authors:  K Taeuber; R Zapf; W Rupp; M Badian
Journal:  Int J Clin Pharmacol Biopharm       Date:  1979-01

5.  The effects of zimeldine and amitriptyline on car driving and psychomotor performance.

Authors:  I Hindmarch; Z Subhan; M J Stoker
Journal:  Acta Psychiatr Scand Suppl       Date:  1983

6.  Critical flicker fusion (CFF) test for sedative effect of antidepressants.

Authors:  G Holmberg
Journal:  Acta Psychiatr Scand Suppl       Date:  1981

7.  A comparison of the effects of single doses of mianserin and amitriptyline on psychomotor tests in normal volunteers.

Authors:  P Crome; B Newman
Journal:  J Int Med Res       Date:  1978       Impact factor: 1.671

8.  Sertraline, 1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a new uptake inhibitor with selectivity for serotonin.

Authors:  B K Koe; A Weissman; W M Welch; R G Browne
Journal:  J Pharmacol Exp Ther       Date:  1983-09       Impact factor: 4.030
  8 in total
  9 in total

1.  Bupropion normalizes cognitive performance in patients with depression.

Authors:  C Thomas Gualtieri; Lynda G Johnson
Journal:  MedGenMed       Date:  2007-01-31

2.  Cognitive function is related to fronto-striatal serotonin transporter levels--a brain PET study in young healthy subjects.

Authors:  Karine Madsen; David Erritzoe; Erik Lykke Mortensen; Anders Gade; Jacob Madsen; William Baaré; Gitte M Knudsen; Steen G Hasselbalch
Journal:  Psychopharmacology (Berl)       Date:  2010-07-10       Impact factor: 4.530

Review 3.  Sertraline. A pharmacoeconomic evaluation of its use in depression.

Authors:  R Davis; M I Wilde
Journal:  Pharmacoeconomics       Date:  1996-10       Impact factor: 4.981

Review 4.  Biomarkers for the effects of selective serotonin reuptake inhibitors (SSRIs) in healthy subjects.

Authors:  G J H Dumont; S J de Visser; A F Cohen; J M A van Gerven
Journal:  Br J Clin Pharmacol       Date:  2005-05       Impact factor: 4.335

Review 5.  The selective serotonin reuptake inhibitor sertraline: its profile and use in psychiatric disorders.

Authors:  G MacQueen; L Born; M Steiner
Journal:  CNS Drug Rev       Date:  2001

6.  EEG profile of litoxetine after single and repeated administration in healthy volunteers.

Authors:  A Patat; S Trocherie; J J Thébault; P Rosenzweig; C Dubruc; G Bianchetti; P L Morselli; L A Court
Journal:  Br J Clin Pharmacol       Date:  1994-02       Impact factor: 4.335

7.  A comparative study of acute and subchronic effects of dothiepin, fluoxetine and placebo on psychomotor and actual driving performance.

Authors:  J G Ramaekers; N D Muntjewerff; J F O'Hanlon
Journal:  Br J Clin Pharmacol       Date:  1995-04       Impact factor: 4.335

Review 8.  Sertraline. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depression and obsessive-compulsive disorder.

Authors:  D Murdoch; D McTavish
Journal:  Drugs       Date:  1992-10       Impact factor: 9.546

9.  The effects of escitalopram on working memory and brain activity in healthy adults during performance of the n-back task.

Authors:  Emma J Rose; Enrico Simonotto; Edgar P Spencer; Klaus P Ebmeier
Journal:  Psychopharmacology (Berl)       Date:  2006-03-09       Impact factor: 4.530
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.