Literature DB >> 31918966

The Sigma-1 Receptor at the Crossroad of Proteostasis, Neurodegeneration, and Autophagy.

Maximilian G Christ1, Albrecht M Clement1, Christian Behl2.   

Abstract

Neurodegenerative diseases are linked to dysfunctional proteostasis and disturbed autophagy. Here, we discuss how the sigma-1 receptor (Sig-1R) may act at the intersection of this interaction, as loss-of-function mutations of this unique chaperone are associated with defective autophagy and its pharmacological activation induces autophagic activity.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  ALS; ER; autophagy; neurodegeneration; sigma-1 receptor

Mesh：

Substances：

Year:  2020        PMID： 31918966     DOI： 10.1016/j.tins.2019.12.002

Source DB:  PubMed          Journal:  Trends Neurosci        ISSN： 0166-2236            Impact factor:   13.837


  11 in total

Review 1.  The Interplay Between Autophagy and RNA Homeostasis: Implications for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.

Authors:  O H Houghton; S Mizielinska; P Gomez-Suaga
Journal:  Front Cell Dev Biol       Date:  2022-04-28

Review 2.  Human Cell Organelles in SARS-CoV-2 Infection: An Up-to-Date Overview.

Authors:  Anna Gorący; Jakub Rosik; Bartosz Szostak; Łukasz Ustianowski; Klaudia Ustianowska; Jarosław Gorący
Journal:  Viruses       Date:  2022-05-19       Impact factor: 5.818

3.  Sigma-1 receptor ablation impedes adipocyte-like differentiation of mouse embryonic fibroblasts.

Authors:  Huan Yang; Hongtao Shen; Jing Li; Kristin I Stanford; Lian-Wang Guo
Journal:  Cell Signal       Date:  2020-08-02       Impact factor: 4.315

Review 4.  Abnormalities of synaptic mitochondria in autism spectrum disorder and related neurodevelopmental disorders.

Authors:  Liliana Rojas-Charry; Leonardo Nardi; Axel Methner; Michael J Schmeisser
Journal:  J Mol Med (Berl)       Date:  2020-12-18       Impact factor: 4.599

Review 5.  Multi-Target Directed Ligands (MTDLs) Binding the σ1 Receptor as Promising Therapeutics: State of the Art and Perspectives.

Authors:  Francesca Serena Abatematteo; Mauro Niso; Marialessandra Contino; Marcello Leopoldo; Carmen Abate
Journal:  Int J Mol Sci       Date:  2021-06-14       Impact factor: 5.923

Review 6.  Repurposing Sigma-1 Receptor Ligands for COVID-19 Therapy?

Authors:  José Miguel Vela
Journal:  Front Pharmacol       Date:  2020-11-09       Impact factor: 5.810

7.  Stimulation of Sigma-1 Receptor Protects against Cardiac Fibrosis by Alleviating IRE1 Pathway and Autophagy Impairment.

Authors:  Jing Qu; Miaoling Li; Dongxu Li; Yanguo Xin; Junli Li; Song Lei; Wenchao Wu; Xiaojing Liu
Journal:  Oxid Med Cell Longev       Date:  2021-01-04       Impact factor: 6.543

8.  Biophysical Evaluation and In Vitro Controlled Release of Two Isomeric Adamantane Phenylalkylamines with Antiproliferative/Anticancer and Analgesic Activity.

Authors:  Marilena Vlachou; Angeliki-Sofia Foscolos; Angeliki Siamidi; Angeliki Syriopoulou; Nikitas Georgiou; Aikaterini Dedeloudi; Antonis D Tsiailanis; Andreas G Tzakos; Thomas Mavromoustakos; Ioannis P Papanastasiou
Journal:  Molecules       Date:  2021-12-21       Impact factor: 4.411

Review 9.  An Update on Psychopharmacological Treatment of Autism Spectrum Disorder.

Authors:  Ramkumar Aishworiya; Tatiana Valica; Randi Hagerman; Bibiana Restrepo
Journal:  Neurotherapeutics       Date:  2022-01-14       Impact factor: 6.088

Review 10.  Novel Therapeutic Target for Prevention of Neurodegenerative Diseases: Modulation of Neuroinflammation with Sig-1R Ligands.

Authors:  Ferenc Bogár; Lívia Fülöp; Botond Penke
Journal:  Biomolecules       Date:  2022-02-25
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