Jun Zhong1, Ashley Jermusyk1, Lang Wu2, Jason W Hoskins1, Irene Collins1, Evelina Mocci3, Mingfeng Zhang1,4, Lei Song5, Charles C Chung5, Tongwu Zhang5, Wenming Xiao6,7, Demetrius Albanes5, Gabriella Andreotti5, Alan A Arslan8,9,10, Ana Babic11, William R Bamlet12, Laura Beane-Freeman5, Sonja Berndt5, Ayelet Borgida13, Paige M Bracci14, Lauren Brais11, Paul Brennan15, Bas Bueno-de-Mesquita16,17,18,19, Julie Buring20,21, Federico Canzian22, Erica J Childs3, Michelle Cotterchio23,24, Mengmeng Du25, Eric J Duell26, Charles Fuchs27, Steven Gallinger13, J Michael Gaziano20,28,29, Graham G Giles30,31,32, Edward Giovannucci11, Michael Goggins33, Gary E Goodman34, Phyllis J Goodman35, Christopher Haiman36, Patricia Hartge5, Manal Hasan37, Kathy J Helzlsouer38, Elizabeth A Holly39, Eric A Klein40, Manolis Kogevinas41,42,43,44, Robert J Kurtz45, Loic LeMarchand46, Núria Malats47, Satu Männistö48, Roger Milne30,31,49, Rachel E Neale50, Kimmie Ng11, Ofure Obazee22, Ann L Oberg12, Irene Orlow25, Alpa V Patel51, Ulrike Peters34, Miquel Porta42,43, Nathaniel Rothman5, Ghislaine Scelo15,30,31, Howard D Sesso20,21, Gianluca Severi52, Sabina Sieri53, Debra Silverman5, Malin Sund54, Anne Tjønneland55,56,57, Mark D Thornquist34, Geoffrey S Tobias5, Antonia Trichopoulou, Stephen K Van Den Eeden58, Kala Visvanathan59, Jean Wactawski-Wende60, Nicolas Wentzensen5, Emily White34,61, Herbert Yu46, Chen Yuan11, Anne Zeleniuch-Jacquotte9,62, Robert Hoover5, Kevin Brown1, Charles Kooperberg34, Harvey A Risch63, Eric J Jacobs64, Donghui Li65, Kai Yu5, Xiao-Ou Shu2, Stephen J Chanock5, Brian M Wolpin11, Rachael Z Stolzenberg-Solomon5, Nilanjan Chatterjee5,66, Alison P Klein3,33, Jill P Smith67, Peter Kraft21,68, Jianxin Shi5, Gloria M Petersen12, Wei Zheng2, Laufey T Amundadottir1. 1. Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. 2. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA. 3. Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD, USA. 4. US Food and Drug Administration, Silver Spring, MD, USA. 5. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. 6. National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA. 7. Division of Molecular Genetics and Pathology, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD, USA. 8. Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY, USA. 9. Department of Population Health, New York University School of Medicine, New York, NY, USA. 10. Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA. 11. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. 12. Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA. 13. Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada. 14. Department of Epidemiology and Biostatistics, University of California, CA, USA. 15. International Agency for Research on Cancer, Lyon, France. 16. Department for Determinants of Chronic Diseases, National Institute for Public Health and the Environment, BA, Bilthoven, The Netherlands. 17. Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands. 18. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. 19. Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. 20. Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA. 21. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 22. Genomic Epidemiology Group, German Cancer Research Center, Heidelberg, Germany. 23. Cancer Care Ontario, University of Toronto, Toronto, Ontario, Canada. 24. Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada. 25. Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 26. Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Bellvitge Biomedical Research Institute, Catalan Institute of Oncology, Barcelona, Spain. 27. Yale Cancer Center, New Haven, CT, USA. 28. Division of Aging, Brigham and Women's Hospital, Boston, MA, USA. 29. Boston VA Healthcare System, Boston, MA, USA. 30. Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, VIC, Australia. 31. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, VIC, Australia. 32. Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia. 33. Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, MD, USA. 34. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. 35. SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. 36. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. 37. Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. 38. Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. 39. Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA. 40. Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA. 41. ISGlobal, Centre for Research in Environmental Epidemiology, Barcelona, Spain. 42. CIBER Epidemiología y Salud Pública, Barcelona, Spain. 43. Hospital del Mar Institute of Medical Research, Universitat Autònoma de Barcelona, Barcelona, Spain. 44. Universitat Pompeu Fabra, Barcelona, Spain. 45. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 46. Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA. 47. Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center, Madrid, Spain. 48. Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland. 49. Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, VIC, Australia. 50. Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia. 51. Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA. 52. Centre de Recherche en Épidémiologie et Santé des Populations (CESP, Inserm U1018), Facultés de Medicine, Université Paris-Saclay, UPS, UVSQ, Gustave Roussy, Villejuif, France. 53. Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy. 54. Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden. 55. Danish Cancer Society Research Center, Copenhagen, Denmark. 56. Department of Public Health, University of Copenhagen, Copenhagen, Denmark. 57. Hellenic Health Foundation, Athens, Greece. 58. Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA. 59. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. 60. Department of Epidemiology and Environmental Health, University at Buffalo, Buffalo, NY, USA. 61. Department of Epidemiology, University of Washington, Seattle, WA, USA. 62. Perlmutter Cancer Center, New York University School of Medicine, New York, NY, USA. 63. Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA. 64. Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, GA, USA. 65. Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. 66. Department of Biostatistics, Bloomberg School of Public Health, Baltimore, MD, USA. 67. Department of Medicine, Georgetown University, Washington, DC, USA. 68. Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA.
Abstract
BACKGROUND: Although 20 pancreatic cancer susceptibility loci have been identified through genome-wide association studies in individuals of European ancestry, much of its heritability remains unexplained and the genes responsible largely unknown. METHODS: To discover novel pancreatic cancer risk loci and possible causal genes, we performed a pancreatic cancer transcriptome-wide association study in Europeans using three approaches: FUSION, MetaXcan, and Summary-MulTiXcan. We integrated genome-wide association studies summary statistics from 9040 pancreatic cancer cases and 12 496 controls, with gene expression prediction models built using transcriptome data from histologically normal pancreatic tissue samples (NCI Laboratory of Translational Genomics [n = 95] and Genotype-Tissue Expression v7 [n = 174] datasets) and data from 48 different tissues (Genotype-Tissue Expression v7, n = 74-421 samples). RESULTS: We identified 25 genes whose genetically predicted expression was statistically significantly associated with pancreatic cancer risk (false discovery rate < .05), including 14 candidate genes at 11 novel loci (1p36.12: CELA3B; 9q31.1: SMC2, SMC2-AS1; 10q23.31: RP11-80H5.9; 12q13.13: SMUG1; 14q32.33: BTBD6; 15q23: HEXA; 15q26.1: RCCD1; 17q12: PNMT, CDK12, PGAP3; 17q22: SUPT4H1; 18q11.22: RP11-888D10.3; and 19p13.11: PGPEP1) and 11 at six known risk loci (5p15.33: TERT, CLPTM1L, ZDHHC11B; 7p14.1: INHBA; 9q34.2: ABO; 13q12.2: PDX1; 13q22.1: KLF5; and 16q23.1: WDR59, CFDP1, BCAR1, TMEM170A). The association for 12 of these genes (CELA3B, SMC2, and PNMT at novel risk loci and TERT, CLPTM1L, INHBA, ABO, PDX1, KLF5, WDR59, CFDP1, and BCAR1 at known loci) remained statistically significant after Bonferroni correction. CONCLUSIONS: By integrating gene expression and genotype data, we identified novel pancreatic cancer risk loci and candidate functional genes that warrant further investigation. Published by Oxford University Press 2020. This work is written by US Government employees and is in the public domain in the US.
BACKGROUND: Although 20 pancreatic cancer susceptibility loci have been identified through genome-wide association studies in individuals of European ancestry, much of its heritability remains unexplained and the genes responsible largely unknown. METHODS: To discover novel pancreatic cancer risk loci and possible causal genes, we performed a pancreatic cancer transcriptome-wide association study in Europeans using three approaches: FUSION, MetaXcan, and Summary-MulTiXcan. We integrated genome-wide association studies summary statistics from 9040 pancreatic cancer cases and 12 496 controls, with gene expression prediction models built using transcriptome data from histologically normal pancreatic tissue samples (NCI Laboratory of Translational Genomics [n = 95] and Genotype-Tissue Expression v7 [n = 174] datasets) and data from 48 different tissues (Genotype-Tissue Expression v7, n = 74-421 samples). RESULTS: We identified 25 genes whose genetically predicted expression was statistically significantly associated with pancreatic cancer risk (false discovery rate < .05), including 14 candidate genes at 11 novel loci (1p36.12: CELA3B; 9q31.1: SMC2, SMC2-AS1; 10q23.31: RP11-80H5.9; 12q13.13: SMUG1; 14q32.33: BTBD6; 15q23: HEXA; 15q26.1: RCCD1; 17q12: PNMT, CDK12, PGAP3; 17q22: SUPT4H1; 18q11.22: RP11-888D10.3; and 19p13.11: PGPEP1) and 11 at six known risk loci (5p15.33: TERT, CLPTM1L, ZDHHC11B; 7p14.1: INHBA; 9q34.2: ABO; 13q12.2: PDX1; 13q22.1: KLF5; and 16q23.1: WDR59, CFDP1, BCAR1, TMEM170A). The association for 12 of these genes (CELA3B, SMC2, and PNMT at novel risk loci and TERT, CLPTM1L, INHBA, ABO, PDX1, KLF5, WDR59, CFDP1, and BCAR1 at known loci) remained statistically significant after Bonferroni correction. CONCLUSIONS: By integrating gene expression and genotype data, we identified novel pancreatic cancer risk loci and candidate functional genes that warrant further investigation. Published by Oxford University Press 2020. This work is written by US Government employees and is in the public domain in the US.
Authors: Alexander Gusev; Arthur Ko; Huwenbo Shi; Gaurav Bhatia; Wonil Chung; Brenda W J H Penninx; Rick Jansen; Eco J C de Geus; Dorret I Boomsma; Fred A Wright; Patrick F Sullivan; Elina Nikkola; Marcus Alvarez; Mete Civelek; Aldons J Lusis; Terho Lehtimäki; Emma Raitoharju; Mika Kähönen; Ilkka Seppälä; Olli T Raitakari; Johanna Kuusisto; Markku Laakso; Alkes L Price; Päivi Pajukanta; Bogdan Pasaniuc Journal: Nat Genet Date: 2016-02-08 Impact factor: 38.330
Authors: Zhaoming Wang; Bin Zhu; Mingfeng Zhang; Hemang Parikh; Jinping Jia; Charles C Chung; Joshua N Sampson; Jason W Hoskins; Amy Hutchinson; Laurie Burdette; Abdisamad Ibrahim; Christopher Hautman; Preethi S Raj; Christian C Abnet; Andrew A Adjei; Anders Ahlbom; Demetrius Albanes; Naomi E Allen; Christine B Ambrosone; Melinda Aldrich; Pilar Amiano; Christopher Amos; Ulrika Andersson; Gerald Andriole; Irene L Andrulis; Cecilia Arici; Alan A Arslan; Melissa A Austin; Dalsu Baris; Donald A Barkauskas; Bryan A Bassig; Laura E Beane Freeman; Christine D Berg; Sonja I Berndt; Pier Alberto Bertazzi; Richard B Biritwum; Amanda Black; William Blot; Heiner Boeing; Paolo Boffetta; Kelly Bolton; Marie-Christine Boutron-Ruault; Paige M Bracci; Paul Brennan; Louise A Brinton; Michelle Brotzman; H Bas Bueno-de-Mesquita; Julie E Buring; Mary Ann Butler; Qiuyin Cai; Geraldine Cancel-Tassin; Federico Canzian; Guangwen Cao; Neil E Caporaso; Alfredo Carrato; Tania Carreon; Angela Carta; Gee-Chen Chang; I-Shou Chang; Jenny Chang-Claude; Xu Che; Chien-Jen Chen; Chih-Yi Chen; Chung-Hsing Chen; Constance Chen; Kuan-Yu Chen; Yuh-Min Chen; Anand P Chokkalingam; Lisa W Chu; Francoise Clavel-Chapelon; Graham A Colditz; Joanne S Colt; David Conti; Michael B Cook; Victoria K Cortessis; E David Crawford; Olivier Cussenot; Faith G Davis; Immaculata De Vivo; Xiang Deng; Ti Ding; Colin P Dinney; Anna Luisa Di Stefano; W Ryan Diver; Eric J Duell; Joanne W Elena; Jin-Hu Fan; Heather Spencer Feigelson; Maria Feychting; Jonine D Figueroa; Adrienne M Flanagan; Joseph F Fraumeni; Neal D Freedman; Brooke L Fridley; Charles S Fuchs; Manuela Gago-Dominguez; Steven Gallinger; Yu-Tang Gao; Susan M Gapstur; Montserrat Garcia-Closas; Reina Garcia-Closas; Julie M Gastier-Foster; J Michael Gaziano; Daniela S Gerhard; Carol A Giffen; Graham G Giles; Elizabeth M Gillanders; Edward L Giovannucci; Michael Goggins; Nalan Gokgoz; Alisa M Goldstein; Carlos Gonzalez; Richard Gorlick; Mark H Greene; Myron Gross; H Barton Grossman; Robert Grubb; Jian Gu; Peng Guan; Christopher A Haiman; Goran Hallmans; Susan E Hankinson; Curtis C Harris; Patricia Hartge; Claudia Hattinger; Richard B Hayes; Qincheng He; Lee Helman; Brian E Henderson; Roger Henriksson; Judith Hoffman-Bolton; Chancellor Hohensee; Elizabeth A Holly; Yun-Chul Hong; Robert N Hoover; H Dean Hosgood; Chin-Fu Hsiao; Ann W Hsing; Chao Agnes Hsiung; Nan Hu; Wei Hu; Zhibin Hu; Ming-Shyan Huang; David J Hunter; Peter D Inskip; Hidemi Ito; Eric J Jacobs; Kevin B Jacobs; Mazda Jenab; Bu-Tian Ji; Christoffer Johansen; Mattias Johansson; Alison Johnson; Rudolf Kaaks; Ashish M Kamat; Aruna Kamineni; Margaret Karagas; Chand Khanna; Kay-Tee Khaw; Christopher Kim; In-Sam Kim; Jin Hee Kim; Yeul Hong Kim; Young-Chul Kim; Young Tae Kim; Chang Hyun Kang; Yoo Jin Jung; Cari M Kitahara; Alison P Klein; Robert Klein; Manolis Kogevinas; Woon-Puay Koh; Takashi Kohno; Laurence N Kolonel; Charles Kooperberg; Christian P Kratz; Vittorio Krogh; Hideo Kunitoh; Robert C Kurtz; Nilgun Kurucu; Qing Lan; Mark Lathrop; Ching C Lau; Fernando Lecanda; Kyoung-Mu Lee; Maxwell P Lee; Loic Le Marchand; Seth P Lerner; Donghui Li; Linda M Liao; Wei-Yen Lim; Dongxin Lin; Jie Lin; Sara Lindstrom; Martha S Linet; Jolanta Lissowska; Jianjun Liu; Börje Ljungberg; Josep Lloreta; Daru Lu; Jing Ma; Nuria Malats; Satu Mannisto; Neyssa Marina; Giuseppe Mastrangelo; Keitaro Matsuo; Katherine A McGlynn; Roberta McKean-Cowdin; Lorna H McNeill; Robert R McWilliams; Beatrice S Melin; Paul S Meltzer; James E Mensah; Xiaoping Miao; Dominique S Michaud; Alison M Mondul; Lee E Moore; Kenneth Muir; Shelley Niwa; Sara H Olson; Nick Orr; Salvatore Panico; Jae Yong Park; Alpa V Patel; Ana Patino-Garcia; Sofia Pavanello; Petra H M Peeters; Beata Peplonska; Ulrike Peters; Gloria M Petersen; Piero Picci; Malcolm C Pike; Stefano Porru; Jennifer Prescott; Xia Pu; Mark P Purdue; You-Lin Qiao; Preetha Rajaraman; Elio Riboli; Harvey A Risch; Rebecca J Rodabough; Nathaniel Rothman; Avima M Ruder; Jeong-Seon Ryu; Marc Sanson; Alan Schned; Fredrick R Schumacher; Ann G Schwartz; Kendra L Schwartz; Molly Schwenn; Katia Scotlandi; Adeline Seow; Consol Serra; Massimo Serra; Howard D Sesso; Gianluca Severi; Hongbing Shen; Min Shen; Sanjay Shete; Kouya Shiraishi; Xiao-Ou Shu; Afshan Siddiq; Luis Sierrasesumaga; Sabina Sierri; Alan Dart Loon Sihoe; Debra T Silverman; Matthias Simon; Melissa C Southey; Logan Spector; Margaret Spitz; Meir Stampfer; Par Stattin; Mariana C Stern; Victoria L Stevens; Rachael Z Stolzenberg-Solomon; Daniel O Stram; Sara S Strom; Wu-Chou Su; Malin Sund; Sook Whan Sung; Anthony Swerdlow; Wen Tan; Hideo Tanaka; Wei Tang; Ze-Zhang Tang; Adonina Tardon; Evelyn Tay; Philip R Taylor; Yao Tettey; David M Thomas; Roberto Tirabosco; Anne Tjonneland; Geoffrey S Tobias; Jorge R Toro; Ruth C Travis; Dimitrios Trichopoulos; Rebecca Troisi; Ann Truelove; Ying-Huang Tsai; Margaret A Tucker; Rosario Tumino; David Van Den Berg; Stephen K Van Den Eeden; Roel Vermeulen; Paolo Vineis; Kala Visvanathan; Ulla Vogel; Chaoyu Wang; Chengfeng Wang; Junwen Wang; Sophia S Wang; Elisabete Weiderpass; Stephanie J Weinstein; Nicolas Wentzensen; William Wheeler; Emily White; John K Wiencke; Alicja Wolk; Brian M Wolpin; Maria Pik Wong; Margaret Wrensch; Chen Wu; Tangchun Wu; Xifeng Wu; Yi-Long Wu; Jay S Wunder; Yong-Bing Xiang; Jun Xu; Hannah P Yang; Pan-Chyr Yang; Yasushi Yatabe; Yuanqing Ye; Edward D Yeboah; Zhihua Yin; Chen Ying; Chong-Jen Yu; Kai Yu; Jian-Min Yuan; Krista A Zanetti; Anne Zeleniuch-Jacquotte; Wei Zheng; Baosen Zhou; Lisa Mirabello; Sharon A Savage; Peter Kraft; Stephen J Chanock; Meredith Yeager; Maria Terese Landi; Jianxin Shi; Nilanjan Chatterjee; Laufey T Amundadottir Journal: Hum Mol Genet Date: 2014-07-15 Impact factor: 6.150
Authors: Yingchang Lu; Alicia Beeghly-Fadiel; Lang Wu; Xingyi Guo; Bingshan Li; Joellen M Schildkraut; Hae Kyung Im; Yian A Chen; Jennifer B Permuth; Brett M Reid; Jamie K Teer; Kirsten B Moysich; Irene L Andrulis; Hoda Anton-Culver; Banu K Arun; Elisa V Bandera; Rosa B Barkardottir; Daniel R Barnes; Javier Benitez; Line Bjorge; James Brenton; Ralf Butzow; Trinidad Caldes; Maria A Caligo; Ian Campbell; Jenny Chang-Claude; Kathleen B M Claes; Fergus J Couch; Daniel W Cramer; Mary B Daly; Anna deFazio; Joe Dennis; Orland Diez; Susan M Domchek; Thilo Dörk; Douglas F Easton; Diana M Eccles; Peter A Fasching; Renée T Fortner; George Fountzilas; Eitan Friedman; Patricia A Ganz; Judy Garber; Graham G Giles; Andrew K Godwin; David E Goldgar; Marc T Goodman; Mark H Greene; Jacek Gronwald; Ute Hamann; Florian Heitz; Michelle A T Hildebrandt; Claus K Høgdall; Antoinette Hollestelle; Peter J Hulick; David G Huntsman; Evgeny N Imyanitov; Claudine Isaacs; Anna Jakubowska; Paul James; Beth Y Karlan; Linda E Kelemen; Lambertus A Kiemeney; Susanne K Kjaer; Ava Kwong; Nhu D Le; Goska Leslie; Fabienne Lesueur; Douglas A Levine; Amalia Mattiello; Taymaa May; Lesley McGuffog; Iain A McNeish; Melissa A Merritt; Francesmary Modugno; Marco Montagna; Susan L Neuhausen; Heli Nevanlinna; Finn C Nielsen; Liene Nikitina-Zake; Robert L Nussbaum; Kenneth Offit; Edith Olah; Olufunmilayo I Olopade; Sara H Olson; Håkan Olsson; Ana Osorio; Sue K Park; Michael T Parsons; Petra H M Peeters; Tanja Pejovic; Paolo Peterlongo; Catherine M Phelan; Miquel Angel Pujana; Susan J Ramus; Gad Rennert; Harvey Risch; Gustavo C Rodriguez; Cristina Rodríguez-Antona; Isabelle Romieu; Matti A Rookus; Mary Anne Rossing; Iwona K Rzepecka; Dale P Sandler; Rita K Schmutzler; Veronica W Setiawan; Priyanka Sharma; Weiva Sieh; Jacques Simard; Christian F Singer; Honglin Song; Melissa C Southey; Amanda B Spurdle; Rebecca Sutphen; Anthony J Swerdlow; Manuel R Teixeira; Soo H Teo; Mads Thomassen; Marc Tischkowitz; Amanda E Toland; Antonia Trichopoulou; Nadine Tung; Shelley S Tworoger; Elizabeth J van Rensburg; Adriaan Vanderstichele; Ana Vega; Digna Velez Edwards; Penelope M Webb; Jeffrey N Weitzel; Nicolas Wentzensen; Emily White; Alicja Wolk; Anna H Wu; Drakoulis Yannoukakos; Kristin K Zorn; Simon A Gayther; Antonis C Antoniou; Andrew Berchuck; Ellen L Goode; Georgia Chenevix-Trench; Thomas A Sellers; Paul D P Pharoah; Wei Zheng; Jirong Long Journal: Cancer Res Date: 2018-07-27 Impact factor: 13.312
Authors: Brian M Wolpin; Cosmeri Rizzato; Peter Kraft; Charles Kooperberg; Gloria M Petersen; Zhaoming Wang; Alan A Arslan; Laura Beane-Freeman; Paige M Bracci; Julie Buring; Federico Canzian; Eric J Duell; Steven Gallinger; Graham G Giles; Gary E Goodman; Phyllis J Goodman; Eric J Jacobs; Aruna Kamineni; Alison P Klein; Laurence N Kolonel; Matthew H Kulke; Donghui Li; Núria Malats; Sara H Olson; Harvey A Risch; Howard D Sesso; Kala Visvanathan; Emily White; Wei Zheng; Christian C Abnet; Demetrius Albanes; Gabriella Andreotti; Melissa A Austin; Richard Barfield; Daniela Basso; Sonja I Berndt; Marie-Christine Boutron-Ruault; Michelle Brotzman; Markus W Büchler; H Bas Bueno-de-Mesquita; Peter Bugert; Laurie Burdette; Daniele Campa; Neil E Caporaso; Gabriele Capurso; Charles Chung; Michelle Cotterchio; Eithne Costello; Joanne Elena; Niccola Funel; J Michael Gaziano; Nathalia A Giese; Edward L Giovannucci; Michael Goggins; Megan J Gorman; Myron Gross; Christopher A Haiman; Manal Hassan; Kathy J Helzlsouer; Brian E Henderson; Elizabeth A Holly; Nan Hu; David J Hunter; Federico Innocenti; Mazda Jenab; Rudolf Kaaks; Timothy J Key; Kay-Tee Khaw; Eric A Klein; Manolis Kogevinas; Vittorio Krogh; Juozas Kupcinskas; Robert C Kurtz; Andrea LaCroix; Maria T Landi; Stefano Landi; Loic Le Marchand; Andrea Mambrini; Satu Mannisto; Roger L Milne; Yusuke Nakamura; Ann L Oberg; Kouros Owzar; Alpa V Patel; Petra H M Peeters; Ulrike Peters; Raffaele Pezzilli; Ada Piepoli; Miquel Porta; Francisco X Real; Elio Riboli; Nathaniel Rothman; Aldo Scarpa; Xiao-Ou Shu; Debra T Silverman; Pavel Soucek; Malin Sund; Renata Talar-Wojnarowska; Philip R Taylor; George E Theodoropoulos; Mark Thornquist; Anne Tjønneland; Geoffrey S Tobias; Dimitrios Trichopoulos; Pavel Vodicka; Jean Wactawski-Wende; Nicolas Wentzensen; Chen Wu; Herbert Yu; Kai Yu; Anne Zeleniuch-Jacquotte; Robert Hoover; Patricia Hartge; Charles Fuchs; Stephen J Chanock; Rachael S Stolzenberg-Solomon; Laufey T Amundadottir Journal: Nat Genet Date: 2014-08-03 Impact factor: 41.307
Authors: Mingfeng Zhang; Zhaoming Wang; Ofure Obazee; Jinping Jia; Erica J Childs; Jason Hoskins; Gisella Figlioli; Evelina Mocci; Irene Collins; Charles C Chung; Christopher Hautman; Alan A Arslan; Laura Beane-Freeman; Paige M Bracci; Julie Buring; Eric J Duell; Steven Gallinger; Graham G Giles; Gary E Goodman; Phyllis J Goodman; Aruna Kamineni; Laurence N Kolonel; Matthew H Kulke; Núria Malats; Sara H Olson; Howard D Sesso; Kala Visvanathan; Emily White; Wei Zheng; Christian C Abnet; Demetrius Albanes; Gabriella Andreotti; Lauren Brais; H Bas Bueno-de-Mesquita; Daniela Basso; Sonja I Berndt; Marie-Christine Boutron-Ruault; Maarten F Bijlsma; Hermann Brenner; Laurie Burdette; Daniele Campa; Neil E Caporaso; Gabriele Capurso; Giulia Martina Cavestro; Michelle Cotterchio; Eithne Costello; Joanne Elena; Ugo Boggi; J Michael Gaziano; Maria Gazouli; Edward L Giovannucci; Michael Goggins; Myron Gross; Christopher A Haiman; Manal Hassan; Kathy J Helzlsouer; Nan Hu; David J Hunter; Elzbieta Iskierka-Jazdzewska; Mazda Jenab; Rudolf Kaaks; Timothy J Key; Kay-Tee Khaw; Eric A Klein; Manolis Kogevinas; Vittorio Krogh; Juozas Kupcinskas; Robert C Kurtz; Maria T Landi; Stefano Landi; Loic Le Marchand; Andrea Mambrini; Satu Mannisto; Roger L Milne; Rachel E Neale; Ann L Oberg; Salvatore Panico; Alpa V Patel; Petra H M Peeters; Ulrike Peters; Raffaele Pezzilli; Miquel Porta; Mark Purdue; J Ramón Quiros; Elio Riboli; Nathaniel Rothman; Aldo Scarpa; Ghislaine Scelo; Xiao-Ou Shu; Debra T Silverman; Pavel Soucek; Oliver Strobel; Malin Sund; Ewa Małecka-Panas; Philip R Taylor; Francesca Tavano; Ruth C Travis; Mark Thornquist; Anne Tjønneland; Geoffrey S Tobias; Dimitrios Trichopoulos; Yogesh Vashist; Pavel Vodicka; Jean Wactawski-Wende; Nicolas Wentzensen; Herbert Yu; Kai Yu; Anne Zeleniuch-Jacquotte; Charles Kooperberg; Harvey A Risch; Eric J Jacobs; Donghui Li; Charles Fuchs; Robert Hoover; Patricia Hartge; Stephen J Chanock; Gloria M Petersen; Rachael S Stolzenberg-Solomon; Brian M Wolpin; Peter Kraft; Alison P Klein; Federico Canzian; Laufey T Amundadottir Journal: Oncotarget Date: 2016-10-11
Authors: Achal Patel; Montserrat García-Closas; Andrew F Olshan; Charles M Perou; Melissa A Troester; Michael I Love; Arjun Bhattacharya Journal: Cancer Res Date: 2021-10-28 Impact factor: 12.701
Authors: Andrea Tóth; Alexandra Demcsák; Florence Zankl; Grzegorz Oracz; Lara Sophie Unger; Peter Bugert; Helmut Laumen; Andrea Párniczky; Péter Hegyi; Jonas Rosendahl; Tomasz Gambin; Rafał Płoski; Dorota Koziel; Stanisław Gluszek; Fredrik Lindgren; J Matthias Löhr; Miklós Sahin-Tóth; Heiko Witt; Agnieszka Magdalena Rygiel; Maren Ewers; Eszter Hegyi Journal: Pancreatology Date: 2022-06-23 Impact factor: 3.977