Literature DB >> 31917111

Stressed-Out T Cells Fragment the Mind.

Evan A Bordt1, Staci D Bilbo2.   

Abstract

The immune system is increasingly recognized to play an integral role in regulating stress responses. In a recent article in Cell, Fan et al. demonstrate a novel mechanism through which stress drives mitochondrial fragmentation-induced xanthine accumulation in mouse CD4+ T cells, subsequently acting on oligodendrocytes to induce anxiety-like behaviors.
Copyright © 2019 Elsevier Ltd. All rights reserved.

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Year:  2020        PMID： 31917111      PMCID： PMC7384651          DOI： 10.1016/j.it.2019.12.008

Source DB:  PubMed          Journal:  Trends Immunol        ISSN： 1471-4906            Impact factor:   16.687


  8 in total

Review 1.  Non-adherence and non-response in the treatment of anxiety disorders.

Authors:  Steven Taylor; Jonathan S Abramowitz; Dean McKay
Journal:  J Anxiety Disord       Date:  2012-02-13

2.  Removal of microglial-specific MyD88 signaling alters dentate gyrus doublecortin and enhances opioid addiction-like behaviors.

Authors:  Phillip D Rivera; Richa Hanamsagar; Matthew J Kan; Phuong K Tran; David Stewart; Young Chan Jo; Michael Gunn; Staci D Bilbo
Journal:  Brain Behav Immun       Date:  2018-11-15       Impact factor: 7.217

3.  Parkin and mitofusins reciprocally regulate mitophagy and mitochondrial spheroid formation.

Authors:  Wen-Xing Ding; Fengli Guo; Hong-Min Ni; Abigail Bockus; Sharon Manley; Donna B Stolz; Eeva-Liisa Eskelinen; Hartmut Jaeschke; Xiao-Ming Yin
Journal:  J Biol Chem       Date:  2012-10-24       Impact factor: 5.157

4.  RAG-1-deficient mice have no mature B and T lymphocytes.

Authors:  P Mombaerts; J Iacomini; R S Johnson; K Herrup; S Tonegawa; V E Papaioannou
Journal:  Cell       Date:  1992-03-06       Impact factor: 41.582

5.  Stress-Induced Metabolic Disorder in Peripheral CD4+ T Cells Leads to Anxiety-like Behavior.

Authors:  Ke-Qi Fan; Yi-Yuan Li; Hao-Li Wang; Xin-Tao Mao; Jin-Xin Guo; Fei Wang; Ling-Jie Huang; Yi-Ning Li; Xiang-Yu Ma; Zheng-Jun Gao; Wei Chen; Dan-Dan Qian; Wen-Jin Xue; Qian Cao; Lei Zhang; Li Shen; Long Zhang; Chao Tong; Jiang-Yan Zhong; Wei Lu; Ling Lu; Ke-Ming Ren; Guisheng Zhong; Yuan Wang; Mingliang Tang; Xin-Hua Feng; Ren-Jie Chai; Jin Jin
Journal:  Cell       Date:  2019-10-31       Impact factor: 41.582

6.  Alpha-synuclein fibrils recruit TBK1 and OPTN to lysosomal damage sites and induce autophagy in microglial cells.

Authors:  Claudio Bussi; Javier M Peralta Ramos; Daniela S Arroyo; Jose I Gallea; Paolo Ronchi; Androniki Kolovou; Ji M Wang; Oliver Florey; Maria S Celej; Yannick Schwab; Nicholas T Ktistakis; Pablo Iribarren
Journal:  J Cell Sci       Date:  2018-11-30       Impact factor: 5.285

7.  Microglial recruitment of IL-1β-producing monocytes to brain endothelium causes stress-induced anxiety.

Authors:  D B McKim; M D Weber; A Niraula; C M Sawicki; X Liu; B L Jarrett; K Ramirez-Chan; Y Wang; R M Roeth; A D Sucaldito; C G Sobol; N Quan; J F Sheridan; J P Godbout
Journal:  Mol Psychiatry       Date:  2017-04-04       Impact factor: 15.992

8.  Microglial activation mediates chronic mild stress-induced depressive- and anxiety-like behavior in adult rats.

Authors:  Ya-Lin Wang; Qiu-Qin Han; Wen-Qing Gong; Dong-Hui Pan; Li-Zheng Wang; Wei Hu; Min Yang; Bing Li; Jin Yu; Qiong Liu
Journal:  J Neuroinflammation       Date:  2018-01-17       Impact factor: 8.322
  8 in total

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