Literature DB >> 31916575

Correlation Between Immunoglobulin Dose Administered and Plasma Neutralization of Streptococcal Superantigens in Patients With Necrotizing Soft Tissue Infections.

Helena Bergsten1, Martin Bruun Madsen2, Francois Bergey3, Ole Hyldegaard4,5, Steinar Skrede6,7, Per Arnell8, Oddvar Oppegaard6, Andreas Itzek9, Anders Perner2, Mattias Svensson1, Anna Norrby-Teglund1.   

Abstract

Analyses of plasma collected pre- and postadministration of intravenous immunoglobulin (IVIG) from patients with group A Streptococcus necrotizing soft tissue infections demonstrated a negative correlation between IVIG dose and toxin-triggered T-cell proliferation (r = -.67, P < .0001). One 25-g IVIG dose was sufficient to yield plasma-neutralizing activity against streptococcal superantigens. Clinical Trials Registration. NCT01790698 and NCT02111161.
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.

Entities:  

Keywords:  zzm321990 Streptococcus pyogeneszzm321990 ; intravenous immunoglobulin G; necrotizing fasciitis; necrotizing soft tissue infections; superantigens

Year:  2020        PMID： 31916575     DOI： 10.1093/cid/ciaa022

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   9.079


  5 in total

1.  Adjunctive Rifampicin Increases Antibiotic Efficacy in Group A Streptococcal Tissue Infection Models.

Authors:  H Bergsten; L M Palma Medina; M Morgan; K Moll; D H Skutlaberg; S Skrede; T Wajima; M Svensson; A Norrby-Teglund
Journal:  Antimicrob Agents Chemother       Date:  2021-09-07       Impact factor: 5.191

2.  Case Report: Therapeutic Strategy With Delayed Debridement for Culture-Negative Invasive Group A Streptococcal Infections Diagnosed by Metagenomic Next-Generation Sequencing.

Authors:  Wenfang He; Chenfang Wu; Yanjun Zhong; Jinxiu Li; Guyi Wang; Bo Yu; Ping Xu; Yiwen Xiao; Tiantian Tang
Journal:  Front Public Health       Date:  2022-05-11

3.  SARS-CoV-2 infection complicated by inflammatory syndrome. Could high-dose human immunoglobulin for intravenous use (IVIG) be beneficial?

Authors:  Marcella Prete; Elvira Favoino; Giacomo Catacchio; Vito Racanelli; Federico Perosa
Journal:  Autoimmun Rev       Date:  2020-05-01       Impact factor: 9.754

Review 4.  Exotoxin-Targeted Drug Modalities as Antibiotic Alternatives.

Authors:  Moona Sakari; Arttu Laisi; Arto T Pulliainen
Journal:  ACS Infect Dis       Date:  2022-01-31       Impact factor: 5.084

Review 5.  Immunomodulation for Severe COVID-19 Pneumonia: The State of the Art.

Authors:  Yinhua Zhang; Yuanyuan Chen; Zhongji Meng
Journal:  Front Immunol       Date:  2020-11-09       Impact factor: 8.786
  5 in total

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