Forest W Arnold1, Andrea M Reyes Vega1, Vidyulata Salunkhe1, Stephen Furmanek1, Christian Furman2,3,4, Laura Morton3,4, Anna Faul4,5,6, Pam Yankeelov4,5, Julio A Ramirez1. 1. Division of Infectious Diseases, Department of Medicine, School of Medicine, University of Louisville, Louisville, Kentucky. 2. Division of General Internal Medicine, Palliative Medicine and Medical Education, Department of Medicine, School of Medicine, University of Louisville, Louisville, Kentucky. 3. Division of Geriatric Medicine, Department of Family and Geriatric Medicine, School of Medicine, University of Louisville, Louisville, Kentucky. 4. Trager Institute, University of Louisville, Louisville, Kentucky. 5. Kent School of Social Work, University of Louisville, Louisville, Kentucky. 6. Department of Social Work, University of the Free State, Bloemfontein, South Africa.
Abstract
OBJECTIVES: To define the current incidence, epidemiology, and mortality of older adult patients hospitalized with community-acquired pneumonia (CAP) in Louisville, KY and thus estimate the burden of CAP in the older adult population of the United States. To define risk factors associated with early and late outcomes. DESIGN: This was a secondary analysis of older adults (aged ≥65 years) from the University of Louisville Pneumonia Study, a prospective population-based cohort study of all hospitalized adults with CAP between June 1, 2014, and May 31, 2016. SETTING: The study took place in all nine acute care hospitals for adults in Louisville, KY. PARTICIPANTS: Residents in the city of Louisville, KY, who were diagnosed with CAP between the inclusion dates were included and who were aged 65 years or older. MEASUREMENTS: Incidence of CAP and outcomes were measured. A total of nine risk factors were also assessed for any potential association with time to clinical stability, length of stay (LOS), and mortality. RESULTS: During the 2-year study, from a Louisville population of 102 264 adults aged 65 years or older, 4760 were hospitalized with CAP. The incidence of older adults hospitalized with CAP was 2093 per 100 000 population. This corresponds to 967 470 older adults in the United States hospitalized per year with CAP. The median time to clinical stability was 2 days, and the median LOS was 6 days. The 30-day all-cause mortality was 17%. The 1-year all-cause mortality was 38% (829 patients), which corresponds to 361 982 deaths in the United States with CAP in older adults. CONCLUSION: The estimated burden of CAP in older adults is substantial in the United States. Nearly 1 million older adults are hospitalized for CAP, and over a third of those die within 1 year. J Am Geriatr Soc 68:1007-1014, 2020.
OBJECTIVES: To define the current incidence, epidemiology, and mortality of older adult patients hospitalized with community-acquired pneumonia (CAP) in Louisville, KY and thus estimate the burden of CAP in the older adult population of the United States. To define risk factors associated with early and late outcomes. DESIGN: This was a secondary analysis of older adults (aged ≥65 years) from the University of Louisville Pneumonia Study, a prospective population-based cohort study of all hospitalized adults with CAP between June 1, 2014, and May 31, 2016. SETTING: The study took place in all nine acute care hospitals for adults in Louisville, KY. PARTICIPANTS: Residents in the city of Louisville, KY, who were diagnosed with CAP between the inclusion dates were included and who were aged 65 years or older. MEASUREMENTS: Incidence of CAP and outcomes were measured. A total of nine risk factors were also assessed for any potential association with time to clinical stability, length of stay (LOS), and mortality. RESULTS: During the 2-year study, from a Louisville population of 102 264 adults aged 65 years or older, 4760 were hospitalized with CAP. The incidence of older adults hospitalized with CAP was 2093 per 100 000 population. This corresponds to 967 470 older adults in the United States hospitalized per year with CAP. The median time to clinical stability was 2 days, and the median LOS was 6 days. The 30-day all-cause mortality was 17%. The 1-year all-cause mortality was 38% (829 patients), which corresponds to 361 982 deaths in the United States with CAP in older adults. CONCLUSION: The estimated burden of CAP in older adults is substantial in the United States. Nearly 1 million older adults are hospitalized for CAP, and over a third of those die within 1 year. J Am Geriatr Soc 68:1007-1014, 2020.
Authors: Lauren J Hunt; R Sean Morrison; Siqi Gan; Edie Espejo; Katherine A Ornstein; W John Boscardin; Alexander K Smith Journal: J Am Geriatr Soc Date: 2022-02-05 Impact factor: 7.538
Authors: Luis F Reyes; Alirio R Bastidas; Eduardo Tuta Quintero; Juan S Frías; Álvaro F Aguilar; Karen D Pedreros; Manuela Herrera; Laura D Saza; Alejandra P Nonzoque; Laura E Bello; Maria D Hernández; Germán A Carmona; Anyelinne Jaimes; Silvia M Ramírez; Natalia Murillo Journal: Can Respir J Date: 2022-06-03 Impact factor: 2.130